6,8-二氢-5H-咪唑并[2,1-c][1,4]噻嗪-3-甲醛合成路线 (共 4 条)
反应条件
1: 2-bromo-3-hydroxypropenal With toluene-4-sulfonic acid; isopropyl alcohol in cyclohexane T=80°C; 2: 3-Iminothiomorpholine hydrochloride With sodium methylate in ethanol T=20°C; 1 h; 3: With triethylamine in chloroform 2.5 h; Heating / reflux;
参考文献
WO2003/93279 A1, ;
Page/Page column 60-61 ;
反应条件
1: 2-bromo-3-hydroxypropenal With toluene-4-sulfonic acid in cyclohexane; isopropyl alcohol T=80°C; 2: 3-Iminothiomorpholine hydrochloride With sodium methylate in ethanol T=20°C; 1 h; 3: With triethylamine in chloroform 2.5 h; Heating / reflux;
参考文献
WO2003/93277 A1, ;
Page/Page column 78-79 ;
反应条件
1: With sodium methylate in methanol T=20°C; 1 h; 2: With triethylamine in chloroform 2.5 h; Heating / reflux;
参考文献
US2006/276445 A1, ;
Page/Page column 16 ;
反应条件
1: With sodium methylate in methanol; ethanol T=20°C; 1 h; 2: With triethylamine in chloroform 2.5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 15 p. 4623 - 4637