N-[2-(4-氨基苯氧基)乙基]-N,N-二甲基胺合成路线 （共 15 条）
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; methanol P=5250.53 Torr; 16 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2008/77885 A2, 2008 ;
Location in patent: Page/Page column 22 ;
WO 2008/077885 A2
反应条件
in water P=3000.3 Torr; 21 h; steel pressure reactor;
参考文献
WO2005/68452 A1, ;
Page/Page column 42 ;
WO 2005/068452 A1
反应条件
hydrogenchloride in ethyl acetate T=25°C; 2 h;
参考文献
Clegg, Nicola J.; Paruthiyil, Sreenivasan; Leitman, Dale C.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5989 - 6003
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=20°C; 17 h; Inert atmosphere;
参考文献
WO2009/141386 A1, ;
Page/Page column 70 ;
WO 2009/141386 A1
反应条件
1: K2CO3 / acetonitrile / Heating 2: K2CO3 / acetonitrile / 80 °C 3: H2 / Pd/C / ethanol / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 16 p. 4981 - 4991
反应条件
diethylazodicarboxylate in tetrahydrofuran
参考文献
US5770615 A1, ;
US 5770615 A
反应条件
1: K2CO3 / acetonitrile / 80 °C 2: H2 / Pd/C / ethanol / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 16 p. 4981 - 4991
反应条件
1: NaH / dimethylformamide 2: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 333 - 336
反应条件
1: 67 percent / cesium carbonate; KI / dimethylformamide / 26.5 h / 25 - 50 °C 2: 79 percent / aq. HCl / ethyl acetate / 2 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5989 - 6003
反应条件
1: 97 percent / aq. NaHCO3; NaCl / CH2Cl2 / 2 h / Heating 2: 67 percent / cesium carbonate; KI / dimethylformamide / 26.5 h / 25 - 50 °C 3: 79 percent / aq. HCl / ethyl acetate / 2 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5989 - 6003
