4-[2-羟基-3-(丙-2-基氨基)丙氧基]苯酚合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Casagrande; Ferrini; Miragoli; Ferrari
Bollettino Chimico Farmaceutico, 1973 , vol. 112, # 7 p. 445 - 454
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Crowther,A.F. et al.
Journal of Medicinal Chemistry, 1969 , vol. 12, # 4 p. 638 - 642
反应条件
1: (i) aq. NaOH, (ii) /BRN= 605259/
2: H2 / Pd-C / ethanol
View Scheme
参考文献
Crowther,A.F. et al.
Journal of Medicinal Chemistry, 1969 , vol. 12, # 4 p. 638 - 642
反应条件
T=28°C; 192 h; Cunninghamella echinulata;
参考文献
Pasutto; Singh; Jamali; Coutts; Abuzar
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 2 p. 177 - 179
反应条件
2: H2 / Pd-C / ethanol
View Scheme
参考文献
Casagrande; Ferrini; Miragoli; Ferrari
Bollettino Chimico Farmaceutico, 1973 , vol. 112, # 7 p. 445 - 454
反应条件
T=28°C; Cunninghamella echinulata; kinetic parameters of para-hydroxylation by micro-organism Cunninghamella echinulata; Rate constantProduct distribution;
参考文献
Pasutto; Singh; Jamali; Coutts; Abuzar
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 2 p. 177 - 179
反应条件
sodium hydride
1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min; Multistep reaction;
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1570 - 1576
