4-氨甲基苯甲酸甲酯盐酸盐合成路线 （共 15 条）
反应条件
thionyl chloride T=20°C; 96 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; BIORUNX; HEO, Jung Nyoung; KIM, Bum Tae; LEE, Hyuk; CHANG, Sung Youn; LEE, Zang Hee; KIM, Seong Hwan; RYOO, Hyun-Mo
Patent: WO2010/131922 A2, 2010 ;
Location in patent: Page/Page column 28 ;
反应条件
methanol; thionyl chloride Reflux;
参考文献
Kohsaka, Yasuhiro; Nakazono, Kazuko; Koyama, Yasuhito; Asai, Shigeo; Takata, Toshikazu
Angewandte Chemie - International Edition, 2011 , vol. 50, # 21 p. 4872 - 4875
反应条件
hydrogenchloride in 1,4-dioxane 1 h;
参考文献
Tamura; Matsushita; Iwama; Harada; Kishimoto; Itoh
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 5 p. 1199 - 1212
反应条件
1: 25 percent / NaHCO3 / dimethylformamide 2: 66 percent / 4 N HCl / dioxane / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 5 p. 1199 - 1212
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 3 h; Inert atmosphereReflux;
参考文献
Varga, Norbert; Sutkeviciute, Ieva; Guzzi, Cinzia; McGeagh, John; Petit-Haertlein, Isabelle; Gugliotta, Serena; Weiser, Joerg; Angulo, Jesus; Fieschi, Franck; Bernardi, Anna
Chemistry - A European Journal, 2013 , vol. 19, # 15 p. 4786 - 4797
反应条件
1: 94 percent / triethylamine / CH2Cl2 / 20 °C 2: 97 percent / LiOH / H2O; tetrahydrofuran / 20 °C View Scheme
参考文献
Uesato, Shinichi; Kitagawa, Manabu; Nagaoka, Yasuo; Maeda, Taishi; Kuwajima, Hiroshi; Yamori, Takao
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 10 p. 1347 - 1349
反应条件
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C 2.2: 0.25 h View Scheme
参考文献
LANTHEUS MEDICAL IMAGING, INC.; CESATI, Richard, R.; HARRIS, Thomas, D.; ROBINSON, Simon, P.; LOOBY, Richard, J.; CHEESMAN, Edward, H.; YALAMANCHILI, Padmaja; CASEBIER, David, S.
Patent: WO2011/5322 A2, 2011 ;
反应条件
calcium carbonate in chloroform; water T=20°C; 16 h;
参考文献
Goodyer, Claire L. M.; Chinje, Edwin C.; Jaffar, Mohammed; Stratford, Ian J.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 19 p. 4189 - 4206
反应条件
1: 91 percent / KOH / H2O; tetrahydrofuran / 20 °C 2: 93 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Gutierrez-Nava, Manuel; Nierengarten, Helene; Masson, Patrick; Van Dorsselaer, Alain; Nierengarten, Jean-Francois
Tetrahedron Letters, 2003 , vol. 44, # 15 p. 3043 - 3046
反应条件
triethanolamine in dichloromethane
参考文献
Ko, Sung-Bo; Oh, Eu-Gene; Kim, Eon-Kyeom; Kim, Won-Yeob; Choi, Dennis W.; Dugan, Laura L.; Koh, Jae-Young; Won, Moo-Ho; Wie, Myung-Bok
Patent: US2003/220337 A1, 2003 ;
