2,6-二甲基-4H-3,1-苯并噁嗪-4-酮合成路线 （共 7 条）
反应条件
ammonium hydroxide in ethanol T=20°C; 48 h;
参考文献
Cao, Sheng-Li; Feng, Yu-Ping; Zheng, Xiao-Lin; Jiang, Yu-Yang; Zhang, Mei; Wang, Yue; Xu, Meng
Archiv der Pharmazie, 2006 , vol. 339, # 5 p. 250 - 254
反应条件
1: 89 percent / aq. NH3 / ethanol / 48 h / 20 °C 2: 76 percent / N-bromosuccinimide; benzoyl peroxide / CHCl3 / 3 h / Heating; UV-irradiation View Scheme
参考文献
Cao, Sheng-Li; Feng, Yu-Ping; Zheng, Xiao-Lin; Jiang, Yu-Yang; Zhang, Mei; Wang, Yue; Xu, Meng
Archiv der Pharmazie, 2006 , vol. 339, # 5 p. 250 - 254
反应条件
potassium tetrachloropalladate; N-ethyl-N,N-diisopropylamine; di-(1-adamantyl)-n-butylphosphine in toluene
T=100°C; P=1500.15 Torr; 16 h; Autoclave;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2012 , vol. 18, # 40 p. 12599 - 12602
反应条件
acetic anhydride in dichloromethane
参考文献
Boehringer Ingelheim KG
Patent: US5116971 A1, 1992 ;
US 5116971 A
参考文献
Mosley, Cara A.; Acker, Timothy M.; Hansen, Kasper B.; Mullasseril, Praseeda; Andersen, Karen T.; Le, Phuong; Vellano, Kimberly M.; Braeuner-Osborne, Hans; Liotta, Dennis C.; Traynelis, Stephen F.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5476 - 5490
反应条件
triphenyl phosphite in pyridine
T=150°C; 0.166667 h; microwave irradiation;
参考文献
Liu, Ji-Feng; Lee, Jaekyoo; Dalton, Audra M.; Bi, Grace; Yu, Libing; Baldino, Carmen M.; McElory, Eric; Brown, Matt
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1241 - 1244
反应条件
in N,N-dimethyl-formamide
T=120°C;
参考文献
Lockman, Jeffrey W.; Murphy, Brett R.; Zigar, Daniel F.; Judd, Weston R.; Slattum, Paul M.; Gao, Zhong-Hua; Ostanin, Kirill; Green, Jeremy; McKinnon, Rena; Terry-Lorenzo, Ryan T.; Fleischer, Tracey C.; Boniface, J. Jay; Shenderovich, Mark; Willardsen, J. Adam
Journal of Medicinal Chemistry, 2010 , vol. 53, # 24 p. 8734 - 8746
