3-溴-3-甲基-1-丁炔合成路线 （共 25 条）
反应条件
in benzene refluxing;;
参考文献
Gmelin Handbook: Sn: Org.Verb.2, 1.1.2.2.7, page 206 - 218
反应条件
aluminum amalgam; mercury dichloride 1.) ether, reflux, 2 h, 2.) ether, RT, 15 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Barbot, F.; Miginiac, Ph.
Journal of Organometallic Chemistry, 1992 , vol. 440, # 3 p. 249 - 261
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 0.75 h;
参考文献
Ruitenberg, K.; Kleijn, H.; Westmijze, H.; Meijer, J.; Vermeer, P.
Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 11 p. 405 - 409
反应条件
1: 39 percent / Na / ethanol / 4 h / 60 °C 2: 82 percent / NaCl/H2O / dimethylsulfoxide / 19 h / 180 °C 3: 95 percent / LiAlH4 / diethyl ether / 1.) reflux, 1 h; 2.) RT, 10 h 4: 73 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / 1 h / -78 °C View Scheme
参考文献
Rank, Elisabeth; Brueckner, Reinhard
European Journal of Organic Chemistry, 1998 , # 6 p. 1045 - 1053
反应条件
sodium azide in hexadeuteroethanol; water-d2 T=20 - 30°C; further solvents, times, temp.; Product distribution;
参考文献
Chemische Berichte, , vol. 122, p. 911 - 918
反应条件
copper(I) bromide in acetonitrile 0.5 h; Ambient temperature;
参考文献
Gazzetta Chimica Italiana, , vol. 124, # 6 p. 241 - 248
反应条件
phosphorus tribromide
Inert atmosphere;
参考文献
Trost, Barry M.; Frontier, Alison J.; Thiel, Oliver R.; Yang, Hanbiao; Dong, Guangbin
Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9762 - 9776
反应条件
methyllithium
T=-40°C;
参考文献
Baird, Mark S.; Hussain, Helmi H.; Nethercott, William
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1845 - 1854
反应条件
methyllithium in diethyl ether
T=-50 - -40°C;
参考文献
Baird, Mark S.; Hussain, Helmi H.; Nethercott, William
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1845 - 1854
反应条件
hydrogen bromide
T=-10 - -5°C; 2 h;
参考文献
Traynard,J.-C.
Bulletin de la Societe Chimique de France, 1962 , p. 19 - 22
