3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: bromine / acetic acid
2: potassium carbonate / dimethylformamide
3: 96 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / rt, 15 min; reflux, 48 h
View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8725 - 8728
参考文献
Hishida
Nippon Kagaku Zasshi, 1958 , vol. 79, p. 709,717
Chem. Zentralbl., 1959 , vol. 130, p. 6808
Full Text Show Details
Zemplen; Bognar
Chemische Berichte, 1942 , vol. 75, p. 1040,1041
反应条件
1: K2CO3 / acetone
2: microwave irradiation
3: 93 percent / K2CO3 / acetone / 2 h / 60 °C
4: 54 percent / [RuClH(CO)(PPh3)3] / CH2Cl2 / 14 h / 65 °C
5: 50 percent / ((Mes)2C3H5N2)Cl2Ru=CHPh / toluene / 3 h / 90 °C
View Scheme
参考文献
Van Otterlo, Willem A.L.; Morgans, Garreth L.; Madeley, Lee G.; Kuzvidza, Samuel; Moleele, Simon S.; Thornton, Natalie; De Koning, Charles B.
Tetrahedron, 2005 , vol. 61, # 32 p. 7746 - 7755
反应条件
1: pyridine; piperidine
2: sodium-amalgam / in alkal. wss. Loesung
3: hydrogen chloride
4: potassium carbonate; methanol
View Scheme
参考文献
Robinson; Sugasawa
Journal of the Chemical Society, 1931 , p. 3163,3168
Journal of the Chemical Society, 1933 , p. 280
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60 - 80°C; 8 h;
参考文献
Ranbaxy Laboratories Limited
Patent: EP1840123 A1, 2007 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With mercury(II) diacetate in ethanol; acetic acid
T=50°C; 0.333333 h;
2: With sodium bromide in ethanol; water; acetic acid
3: With N-methylpyrrolidine-2-one hydrotribromide in acetonitrile
T=20°C; 0.333333 h; regioselective reaction;
参考文献
Rasolofonjatovo, Evelia; Provot, Olivier; Hamze, Abdallah; Rodrigo, Jordi; Bignon, Jerome; Wdzieczak-Bakala, Joanna; Lenoir, Christine; Desravines, Deborah; Dubois, Joelle; Brion, Jean-Daniel; Alami, Mouad
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 28 - 39
反应条件
1: in ethanol
T=20°C; 0.0833333 h;
2: With sodium hydroxide in ethanol
T=20°C;
参考文献
Anand, Preet; Singh, Baldev
Medicinal Chemistry Research, 2013 , vol. 22, # 4 p. 1648 - 1659
反应条件
1: potassium carbonate / 60 °C
2: potassium permanganate / acetone / |Reflux
3: thionyl chloride / |Reflux
4: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C
5: acetic acid; iron / methanol
View Scheme
参考文献
Zhao, Feng; Lin, Zhaohu; Wang, Feng; Zhao, Weili; Dong, Xiaochun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5385 - 5388
反应条件
1: K2CO3 / dimethylformamide / 5 h / 40 - 50 °C
2: NaBH4, 0.5N aq. NaOH / tetrahydrofuran / 2.5 h / Ambient temperature
3: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature
4: 18-crown-6 / acetonitrile / 7 h / Heating
5: aq. KOH / ethanol / 4 h / Heating
6: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Resch, Verena; Lechner, Horst; Schrittwieser, Joerg H.; Wallner, Silvia; Gruber, Karl; MacHeroux, Peter; Kroutil, Wolfgang
Chemistry - A European Journal, 2012 , vol. 18, # 41 p. 13173 - 13179
反应条件
1.1: K2CO3 / ethanol / 2 h / 75 °C
2.1: 100 percent / sodium acetate / 0.08 h / microwave irradiation
3.1: NaOH / 90 °C
3.2: 81 percent / H2O2
4.1: LAH
View Scheme
参考文献
Yasui, Yoshizumi; Koga, Yukiko; Suzuki, Keisuke; Matsumoto, Takashi
Synlett, 2004 , # 4 p. 615 - 618
