1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 20 °C 2.1: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere 3.2: Cooling with ice View Scheme

T=180°C; P=1.5 Torr;

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 0 - 20 °C 2: copper diacetate / N,N-dimethyl-formamide / 120 °C View Scheme

(i) nBuLi, THF, hexane, (ii) /BRN= 969135/; Multistep reaction;

(i) nBuLi, THF, hexane, (ii) /BRN= 385801/; Multistep reaction;

Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 20 °C2: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C