2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚合成路线 (共 10 条)
反应条件
palladium 10 on activated carbon; hydrogen in ethanol; water T=70°C; P=760.051 Torr; 24 h;
参考文献
Kalin, Jay H.; Butler, Kyle V.; Akimova, Tatiana; Hancock, Wayne W.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 639 - 651
反应条件
potassium hydroxide in isopropyl alcohol 16 h; Reflux;
参考文献
Bonjoch, Josep; Diaba, Faiza; Pages, Lluis; Perez, Daniel; Soca, Lidia; Miralpeix, Montserrat; Vilella, Dolors; Anton, Paquita; Puig, Carles
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4299 - 4302
反应条件
1: With sulfuric acid in 1,4-dioxane 2: With hydrogen; palladium in ethanol; water
参考文献
WO2011/11186 A2, ;
Page/Page column 62 ;
WO 2011/011186 A2
反应条件
hydrogenchloride in ethanol; water T=80°C; Fischer indole synthesis;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 14 p. 6363 - 6374
反应条件
sodium in butan-1-ol
参考文献
Eftink, Maurice R.; Jia, Yiwei; Hu, Dana; Ghiron, Camillo, A.
Journal of Physical Chemistry, 1995 , vol. 99, p. 5713 - 5723
反应条件
1: ethanol / 3 h / Heating 2: KOH / aq. ethanol; H2O / 22 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 5 p. 717 - 722
反应条件
1: ethanol / 3 h / Heating 2: KOH / aq. ethanol; H2O / 22 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 5 p. 717 - 722
反应条件
1: sulfuric acid / 1,4-dioxane / 2 h / 60 °C 2: palladium 10 on activated carbon; hydrogen / ethanol; water / 24 h / 70 °C / 760.05 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 2 p. 639 - 651
反应条件
in tetrahydrofuran
T=5 - 20°C;
参考文献
Bonjoch, Josep; Diaba, Faiza; Pages, Lluis; Perez, Daniel; Soca, Lidia; Miralpeix, Montserrat; Vilella, Dolors; Anton, Paquita; Puig, Carles
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4299 - 4302
反应条件
sodium cyanoborohydride in methanol
T=20°C; 3 h;
参考文献
Kalin, Jay H.; Butler, Kyle V.; Akimova, Tatiana; Hancock, Wayne W.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 639 - 651