potassium carbonate in PEG-400 T=100°C; 3 h; Inert atmosphere;

1.1: sodium hydride; 18-crown-6 ether / N,N-dimethyl-formamide / 20 °C / |Inert atmosphere 1.2: 4 h / 60 °C / |Inert atmosphere 2.1: sodium hydrogencarbonate / ethanol; water / |Reflux 3.1: pyrrolidine / ethanol / 14 h / |Reflux View Scheme

triethylamine in diethyl ether T=-10 - 0°C;

trifluoroacetic anhydride in hydrogenchloride; diethyl ether

potassium carbonate in PEG-400 T=100°C; 3 h; Inert atmosphere;