(2S,3R)-3-(Boc-氨基)-2-羟基-4-苯基丁酸合成路线 （共 25 条）
反应条件
sodium hydroxide in water; toluene T=60°C;
参考文献
Tetrahedron Letters, , vol. 42, # 36 p. 6337 - 6340
反应条件
sodium hydroxide in water; toluene T=60°C;
参考文献
Tetrahedron Letters, , vol. 42, # 36 p. 6337 - 6340
反应条件
lithium hydroxide in tetrahydrofuran; methanol
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 2 p. 211 - 220
反应条件
TEA in tetrahydrofuran; water
参考文献
Sheha, Mahmoud M.; Mahfouz, Nadia M.; Hassan, Hoda Y.; Youssef, Adel F.; Mimoto, Tsutomu; Kiso, Yoshiaki
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 10 p. 887 - 894
反应条件
1: 10N NaOH, Na2CO3 / H2O; tetrahydrofuran / Ambient temperature 2: KHCO3 / dimethylformamide / 12 h 3: aq. LiOH / methanol; tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 2 p. 211 - 220
反应条件
1: NaHCO3 / H2O; tetrahydrofuran / Ambient temperature 2: diisobutylaluminium hydride / toluene; hexane / -77 °C 3: sodium metabisulfite / H2O / 5 h / Ambient temperature 4: 25percent aq. HCl / 12 h / 80 °C 5: 10N NaOH, Na2CO3 / H2O; tetrahydrofuran / Ambient temperature 6: KHCO3 / dimethylformamide / 12 h 7: aq. LiOH / methanol; tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 2 p. 211 - 220
反应条件
1: 10N NaOH, Na2CO3 / H2O; tetrahydrofuran / Ambient temperature 2: KHCO3 / dimethylformamide / 12 h 3: aq. LiOH / methanol; tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 2 p. 211 - 220
反应条件
1: KHCO3 / dimethylformamide / 12 h 2: aq. LiOH / methanol; tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 2 p. 211 - 220
反应条件
1: 25percent aq. HCl / 12 h / 80 °C 2: 10N NaOH, Na2CO3 / H2O; tetrahydrofuran / Ambient temperature 3: KHCO3 / dimethylformamide / 12 h 4: aq. LiOH / methanol; tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 2 p. 211 - 220
反应条件
1.1: pyridine*SO3; TEA / dimethylsulfoxide; benzene / -15 °C 2.1: H2O; ethyl acetate 2.2: 6.45 g / conc. HCl / dioxane / 8 h / Heating 3.1: 32.5 percent / TEA / tetrahydrofuran; H2O View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 35, # 10 p. 887 - 894
