(2S,3s)-3-氨基-2-羟基-4-苯基丁酸合成路线 （共 23 条）
反应条件
1: HCl 2: H2 / Pd/C / methanol / 15 h / Ambient temperature 3: aq. NaOH / tetrahydrofuran / 0.5 h / 0 °C 4: triphenylphosphine, diethyldiazodicarboxylate / tetrahydrofuran / 28 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
反应条件
1: H2 / Pd/C / methanol / 15 h / Ambient temperature 2: aq. NaOH / tetrahydrofuran / 0.5 h / 0 °C 3: 79 percent / BBr3 / CH2Cl2 / 2 h / -78 - 20 °C 4: triphenylphosphine, diethyldiazodicarboxylate / tetrahydrofuran / 28 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
反应条件
1: H2 / Pd/C / methanol / 15 h / Ambient temperature 2: aq. NaOH / tetrahydrofuran / 0.5 h / 0 °C 3: triphenylphosphine, diethyldiazodicarboxylate / tetrahydrofuran / 28 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
反应条件
1: 62 percent / LiHMDS, 3-phenyl-2-(phenylsulfonyl)oxaziridine / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 1 h 2: 86 percent / HCl, H2, H2O / 10 percent Pd/C / methanol; dioxane / 4 h / 25 °C 3: 85 percent / HCl, H2O / 3 h / Heating View Scheme
参考文献
Synthesis, , # 6 p. 924 - 926
反应条件
1: 86 percent / HCl, H2, H2O / 10 percent Pd/C / methanol; dioxane / 4 h / 25 °C 2: 85 percent / HCl, H2O / 3 h / Heating View Scheme
参考文献
Synthesis, , # 6 p. 924 - 926
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 510 - 515
反应条件
2: H2 / Pd View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 510 - 515
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 28 h; Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
反应条件
1: aq. NaOH / tetrahydrofuran / 0.5 h / 0 °C 2: triphenylphosphine, diethyldiazodicarboxylate / tetrahydrofuran / 28 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
反应条件
1: 79 percent / BBr3 / CH2Cl2 / 2 h / -78 - 20 °C 2: triphenylphosphine, diethyldiazodicarboxylate / tetrahydrofuran / 28 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
