4,5,6,7-四氢噻吩并[2,3-c]吡啶合成路线 （共 4 条）
反应条件
1: With hydrogenchloride in water T=80 - 85°C; 0.5 h; 2: With sodium hydrogencarbonate in water T=20°C;
参考文献
Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey
Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396
反应条件
n-butyllithium Multistep reaction;
参考文献
Katano, Kiyoaki; Shitara, Eiki; Shimizu, Masaro; Sasaki, Kazue; Miura, Tomoaki; Isomura, Yasuko; Kawaguchi, Mami; Ohuchi, Shokichi; Tsuruoka, Takashi
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 21 p. 2601 - 2606
反应条件
1.1: potassium carbonate / methanol; water / 0.17 h / 25 °C 1.2: 6 h / 60 - 65 °C 2.1: hydrogenchloride / water; acetone / 25 °C View Scheme
参考文献
Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey
Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396
反应条件
1: 2-chloro-α-methoxycarbonylbenzyl bromide With potassium carbonate in methanol; water T=25°C; 0.166667 h; 2: 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine in methanol; water T=60 - 65°C; 6 h;
参考文献
Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey
Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396
