4-甲基-N-苯基苯胺合成路线 （共 140 条）
反应条件
1: p-toluidine With copper diacetate in acetonitrile T=-5°C; 0.25 h; 2: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in acetonitrile T=-5°C; 0.0833333 h; 3: phenylhydrazine in acetonitrile T=-5°C; 3.33333 h;
参考文献
Jadhav, Ravindra R.; Huddar, Sameerana N.; Akamanchi, Krishnacharya G.
European Journal of Organic Chemistry, 2013 , # 30 p. 6779 - 6783
反应条件
1: 4-MeC6H4Si(OMe)3 With tetrabutyl ammonium fluoride; copper diacetate; RF-PPh3 in dichloromethane; water T=20°C; 0.0833333 h; Molecular sieve; 2: aniline With oxygen in dichloromethane; water T=20°C; 24 h;
参考文献
Lin, Baoda; Liu, Miaochang; Ye, Zhishi; Ding, Jinchang; Wu, Huayue; Cheng, Jiang
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 5 p. 869 - 873
反应条件
1: phenyl trimethoxy silane With tetrabutyl ammonium fluoride; copper diacetate; RF-PPh3 in dichloromethane; water T=20°C; 0.0833333 h; Molecular sieve; 2: p-toluidine With oxygen in dichloromethane; water T=20°C; 24 h;
参考文献
Lin, Baoda; Liu, Miaochang; Ye, Zhishi; Ding, Jinchang; Wu, Huayue; Cheng, Jiang
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 5 p. 869 - 873
反应条件
copper(II) bis(trifluoromethanesulfonate) in dichloromethane T=20°C;
参考文献
Journal of Organic Chemistry, , vol. 68, # 14 p. 5627 - 5631
反应条件
copper diacetate; triethylamine in dichloromethane T=20°C; Ullmann condensation; 24 h; In air;
参考文献
Qin, Weiwei; Kakusawa, Naoki; Wu, Yichen; Yasuike, Shuji; Kurita, Jyoji
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 4 p. 436 - 438
反应条件
1: 1-(iodo)-4-methylbenzene With iodine; magnesium in diethyl ether Grignard reaction; Inert atmosphere; 2: With copper (I) cyanide in tetrahydrofuran; diethyl ether T=0°C; Inert atmosphere; 3: diazoaminobenzene in tetrahydrofuran; diethyl ether T=0°C; 2 h; Inert atmosphere;
参考文献
Yadav; Reddy, B.V. Subba; Borkar, Prashant; Reddy, P. Janardhan
Tetrahedron Letters, 2009 , vol. 50, # 48 p. 6642 - 6645
反应条件
C46H58Br2N4O10Pd; potassium tert-butylate in ethylene glycol dimethyl ether T=80°C; 15 h; Inert atmosphereBuchwald-Hartwig amination;
参考文献
Applied Organometallic Chemistry, , vol. 25, # 3 p. 163 - 167
反应条件
copper diacetate; triethylamine in dichloromethane T=20°C; Ullmann condensation; 24 h; In air;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 57, # 4 p. 436 - 438
反应条件
copper diacetate in dichloromethane 48 h; Ambient temperature;
参考文献
Barton, Derek H. R.; Yadav-Bhatnagar, Neerja; Finet, Jean-Pierre; Khamsi, Jamal
Tetrahedron Letters, 1987 , vol. 28, # 27 p. 3111 - 3114
反应条件
copper in dichloromethane 0.75 h; Ambient temperature;
参考文献
Barton, Derek H. R.; Finet, Jean-Pierre; Khamsi, Jamal
Tetrahedron Letters, 1986 , vol. 27, # 31 p. 3615 - 3618
