1-乙酰基-2,3-二氢-5-碘吲哚合成路线 （共 7 条）
反应条件
1: 86 percent / NaOH (40percent) / H2O; methanol / 0.5 h / Heating 2: 71 percent / salcomine / methanol / 5 h / Ambient temperature View Scheme
参考文献
Somei, Masanori; Saida, Yoshihiro; Funamoto, Tetsuo; Ohta, Toshihara
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3146 - 3154
反应条件
sodium hydroxide in methanol; water 0.5 h; Heating;
参考文献
Somei, Masanori; Saida, Yoshihiro; Funamoto, Tetsuo; Ohta, Toshihara
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3146 - 3154
反应条件
1: 86 percent / NaOH (40percent) / H2O; methanol / 0.5 h / Heating 2: 71 percent / salcomine / methanol / 5 h / Ambient temperature 3: 89 percent / POCl3 / 17 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 35, # 8 p. 3146 - 3154
反应条件
copper(l) iodide; triethylamine; N-methyl-2-(methylamino)ethylamine in 1,4-dioxane
72 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD
Patent: WO2007/58602 A2, 2007 ;
Location in patent: Page/Page column 121-122 ;
WO 2007/058602 A2
反应条件
N-iodo-succinimide; acetic acid
T=100°C; 12 h;
参考文献
Kalyani, Dipannita; Dick, Allison R.; Anani, Waseem Q.; Sanford, Melanie S.
Tetrahedron, 2006 , vol. 62, # 49 p. 11483 - 11498
反应条件
1: 100 percent / Heating
2: 1.) thallium tris-trifluoroacetate, trfluoroacetic acid, 2.) aq. potassium iodide
View Scheme
参考文献
Somei, Masanori; Saida, Yoshihiro
Heterocycles, 1985 , vol. 23, # 12 p. 3113 - 3114
反应条件
trifluoroacetic acid; potassium iodide; Tl(OCOCF3)3
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Somei, Masanori; Saida, Yoshihiro
Heterocycles, 1985 , vol. 23, # 12 p. 3113 - 3114
