5-甲氧基-1,2,3,4-四氢-1-萘酚合成路线 （共 11 条）
反应条件
toluene-4-sulfonic acid in chlorobenzene T=132°C; Friedel-Crafts alkylation; 2 h; Title compound not separated from byproducts.;
参考文献
Penick, Mark A.; Mahindaratne, Mathew P. D.; Gutierrez, Robert D.; Smith, Terrill D.; Tiekink, Edward R. T.; Negrete, George R.
Journal of Organic Chemistry, 2008 , vol. 73, # 16 p. 6378 - 6381
反应条件
1: NaH / toluene / 1 h / Heating 2: 55 percent / BBr3 / CH2Cl2 / 6.5 h / -78 - 20 °C View Scheme
参考文献
Banerjee; Poon; Laya; Azocar
Russian Journal of General Chemistry, 2003 , vol. 73, # 11 p. 1815 - 1820
反应条件
4-chloro-1-ethenylbenzene; [N,N'-bis(2-cyclohexyloxycarbonyl-3-oxobutylidene)-(1S,2S)-dimesitylethylenediaminato]cobalt(II); oxygen in tert-butyl alcohol T=20 - 50°C; Resolution of racemate; optical yield given as percent ee;
参考文献
Yamada, Tohru; Higano, Sho; Yano, Takanori; Yamashita, Yoshihiro
Chemistry Letters, 2009 , vol. 38, # 1 p. 40 - 41
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 14 h;
参考文献
Geiseler, Oliver; Mueller, Monika; Podlech, Joachim
Tetrahedron, 2013 , vol. 69, # 18 p. 3683 - 3689
反应条件
bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; cesium fluoride in toluene
T=100°C; Inert atmosphere;
参考文献
Bouffard, Jean; Itami, Kenichiro
Organic Letters, 2009 , vol. 11, # 19 p. 4410 - 4413
反应条件
caesium carbonate in toluene
8 h; Heating;
参考文献
Carlsen, Per H.J.; Liberkova, Katerina; Harrex, Rachel; Roe, Johan
Acta Chemica Scandinavica, 1997 , vol. 51, # 3 p. 343 - 344
反应条件
methanol; sodium
Kochen des Reaktionsgemisches mit Methyljodid;
参考文献
Hardegger; Redlich; Gal
Helvetica Chimica Acta, 1945 , vol. 28, p. 628,633
反应条件
1: ethanol; nickel /kieselguhr / 120 °C / 55898.6 Torr / Hydrogenation
2: methanol; sodium / Kochen des Reaktionsgemisches mit Methyljodid
View Scheme
参考文献
Hardegger; Redlich; Gal
Helvetica Chimica Acta, 1945 , vol. 28, p. 628,633
反应条件
toluene-4-sulfonic acid in benzene
T=70°C; 6 h;
参考文献
Penick, Mark A.; Mahindaratne, Mathew P. D.; Gutierrez, Robert D.; Smith, Terrill D.; Tiekink, Edward R. T.; Negrete, George R.
Journal of Organic Chemistry, 2008 , vol. 73, # 16 p. 6378 - 6381
反应条件
thionyl chloride
Title compound not separated from byproducts;
参考文献
Perrone, R; Berardi, F; Tortorella, V; Govoni, S; Lograno, MD; Daniele, E
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 869 - 874
