1: With thionyl chloride in tetrahydrofuran; 1,4-dioxane T=30°C; Inert atmosphere; 2: With triethylamine in 1,4-dioxane T=30°C; 3: With hydrogenchloride in 1,4-dioxane; water pH=2;

triethylamine in tetrahydrofuran

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 20 °C / Cooling with ice; Inert atmosphere 1.2: 0.5 h / Reflux 2.1: thionyl chloride / 1,4-dioxane; tetrahydrofuran / 30 °C / Inert atmosphere 2.2: 30 °C 2.3: pH 2 View Scheme

1.1: sulfuric acid / ethanol; methanol / 24 h / Reflux 2.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 20 °C / Cooling with ice; Inert atmosphere 2.2: 0.5 h / Reflux 3.1: thionyl chloride / 1,4-dioxane; tetrahydrofuran / 30 °C / Inert atmosphere 3.2: 30 °C 3.3: pH 2 View Scheme

triethylamine; trichlorophosphate T=150°C; 0.5 h; Microwave irradiation;