顺-1,4-环己烷二甲酸合成路线

参考文献

Mitsui Chemicals, Inc.; YOSHIMURA, Naritoshi; KIYONO, Shinji; HAMADA, Tetsuya; WATANABE, Eiji; SAWADA, Saiko
Patent: EP2626344 A1, 2013 ;

619-81-8顺-1,4-环己烷二甲酸

105-08-81,4-环己烷二甲醇

参考文献

ACHAOGEN, INC.; KASAR, Ramesh; LINSELL, Martin Sheringham; AGGEN, James Bradley; LU, Qing (Jane); WANG, Dan; CHURCH, Tim; MOSER, Heinz E.; PATTEN, Phillip A.
Patent: WO2012/154204 A1, 2012 ;

619-81-8顺-1,4-环己烷二甲酸

18720-35-94-(甲氧羰基)双环[2.2.2]辛烷-1-羧酸

参考文献

SIGNAL PHARMACEUTICALS, LLC; BENNETT, Brydon, L.; ELSNER, Jan; ERDMAN, Paul; HILGRAF, Robert; LEBRUN, Laurie, Ann; MCCARRICK, Meg; MOGHADDAM, Mehran, F.; NAGY, Mark, A.; NORRIS, Stephen; PAISNER, David, A.; SLOSS, Marianne; ROMANOW, William, J.; SATOH, Yoshitaka; TIKHE, Jayashree; YOON, Won, Hyung; DELGADO, Mercedes
Patent: WO2012/145569 A1, 2012 ;

619-81-8顺-1,4-环己烷二甲酸+

18107-18-1三甲基硅烷化重氮甲烷

3399-21-1二甲基顺式-1,4-环己烷二羧酸酯

参考文献

Sankyo Company, Limited
Patent: US5843973 A1, 1998 ;

67-56-1甲醇+

619-81-8顺-1,4-环己烷二甲酸

3399-21-1二甲基顺式-1,4-环己烷二羧酸酯

参考文献

Kawai, Makoto; Sakurada, Isao; Morita, Asato; Iwamuro, Yuko; Ando, Kazuo; Omura, Hirofumi; Sakakibara, Sachiko; Masuda, Tsutomu; Koike, Hiroki; Honma, Teruki; Hattori, Kazunari; Takashima, Tadayuki; Mizuno, Kunihiko; Mizutani, Mayumi; Kawamura, Mitsuhiro
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5537 - 5542

7647-01-0盐酸+

619-81-8顺-1,4-环己烷二甲酸

3399-21-1二甲基顺式-1,4-环己烷二羧酸酯

参考文献

Smith; Byrne
Journal of the American Chemical Society, 1950 , vol. 72, p. 4406,4408

186581-53-3重氮甲烷+

619-81-8顺-1,4-环己烷二甲酸

3399-21-1二甲基顺式-1,4-环己烷二羧酸酯

参考文献

Malachowski; Jankiewiczowna
Chemische Berichte, 1934 , vol. 67, p. 1783,1786, 1787

619-81-8顺-1,4-环己烷二甲酸

619-82-9反式-1,4-环己烷二羧酸

参考文献

Baeyer
Justus Liebigs Annalen der Chemie, 1888 , vol. 245, p. 178

7647-01-0盐酸+

619-81-8顺-1,4-环己烷二甲酸

619-82-9反式-1,4-环己烷二羧酸

参考文献

Baeyer
Justus Liebigs Annalen der Chemie, 1888 , vol. 245, p. 178

619-81-8顺-1,4-环己烷二甲酸

1459-96-7双环[2.2.2]辛烷-1,4-二羧酸二甲酯

参考文献

SIGNAL PHARMACEUTICALS, LLC; BENNETT, Brydon, L.; ELSNER, Jan; ERDMAN, Paul; HILGRAF, Robert; LEBRUN, Laurie, Ann; MCCARRICK, Meg; MOGHADDAM, Mehran, F.; NAGY, Mark, A.; NORRIS, Stephen; PAISNER, David, A.; SLOSS, Marianne; ROMANOW, William, J.; SATOH, Yoshitaka; TIKHE, Jayashree; YOON, Won, Hyung; DELGADO, Mercedes
Patent: WO2012/145569 A1, 2012 ;