反应条件
1: 4-ethyl benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
Acylation;
2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran
Substitution; decarboxylation;
参考文献
Boyd, Steven A.; Mantei, Robert A.; Tasker, Andrew S.; Liu, Gang; Sorensen, Bryan K.; Henry Jr., Kenneth J.; Von Geldern, Thomas W.; Winn, Martin; Wu-Wong, Jinshyun R.; Chiou, William J.; Dixon, Douglas B.; Hutchins, Charles W.; Marsh, Kennan C.; Nguyen, Bach; Opgenorth, Terry J.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 991 - 1002
