反应条件
1: 75.8 percent / triphenylphosphine, diethylamine, copper(I) iodide / palladium chloride / 18 h / Ambient temperature
2: 2.60 g / H2 / 5percent palladium-on-charcoal / ethanol / 12 h / 2585.7 Torr
3: triethylamine / diethyl ether / 4 h / 0 - 20 °C
4: 1.) NaH / 1.) THF, 0 deg C -> room temperature, 2.) room temperature, 12 h; reflux, 6 h
5: 1.) sodium methoxide / 1.) anhydrous methanol, nitrogen atmosphere, 0.5 h, 2.) anhydrous dimethylformamide, mild warming, 12 h
6: 2.33 g / 1N sodium hydroxide / 18 h / Ambient temperature
View Scheme
参考文献
Taylor, Edward C.; Harrington, Philip M.; Shih, Chuan
Heterocycles, 1989 , vol. 28, # 2 p. 1169 - 1178
