2,2,2-三氟-N-苯基亚氨代乙酰氯合成路线 （共 10 条）
反应条件
pyridine; trichlorophosphate T=160°C; 4 h; Autoclaveneat (no solvent);
参考文献
Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua
Molecules, 2012 , vol. 17, # 4 p. 4533 - 4544
反应条件
tetrachloromethane; triethylamine; triphenylphosphine
参考文献
Dalton Transactions, , # 43 p. 9452 - 9465
反应条件
chlorine in tetrachloromethane
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 12, p. 2148 - 2151
Zhurnal Organicheskoi Khimii, , vol. 12, p. 2213 - 2217
反应条件
1: dichloromethane / 3 h / 20 °C 2: tetrachloromethane; triphenylphosphine / dichloromethane / 4 h / 60 °C View Scheme
参考文献
Journal of Carbohydrate Chemistry, , vol. 29, # 2 p. 61 - 75
反应条件
1: potassium carbonate 2: trifluoroacetic acid / dimethylsulfoxide-d6 / 2 h View Scheme
参考文献
Tsabedze, Sinele B.; Kabotso, Daniel E.K.; Pohl, Nicola L.B.
Tetrahedron Letters, 2013 , vol. 54, # 51 p. 6983 - 6985
反应条件
sodium hydride in dichloromethane T=20°C; 2 h;
参考文献
Chemistry Letters, , vol. 36, # 8 p. 992 - 993
反应条件
1: sodium hydrosulfide monohydrate / ethanol / 20 °C
2: ammonium cerium (IV) nitrate; sodium hydrogencarbonate / acetonitrile / 0.5 h / 80 °C
View Scheme
参考文献
Zhu, Jiangtao; Xie, Haibo; Li, Shan; Chen, Zixian; Wu, Yongming
Journal of Fluorine Chemistry, 2011 , vol. 132, # 5 p. 306 - 309
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: 1 h / 210 °C
View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1: N-phenyltrifluoroacetimidoyl chloride With methyl phosphonic acid,diethyl ester; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-70°C; 1.5 h;
2: 4-methyl-benzaldehyde in tetrahydrofuran; hexane
T=20°C; 16 h;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
4 h;
参考文献
Laboratorios del Dr. Esteve, S.A.
Patent: US6353117 B1, 2002 ;
Location in patent: Page column 8-9 ;
反应条件
sodium hydrogen sulfide hydrate in ethanol
T=20°C;
参考文献
Zhu, Jiangtao; Xie, Haibo; Li, Shan; Chen, Zixian; Wu, Yongming
Journal of Fluorine Chemistry, 2011 , vol. 132, # 5 p. 306 - 309
