2-(4-羟基-3-硝基苯基)乙酸甲酯合成路线 （共 13 条）
反应条件
hydrogenchloride in water Heating / reflux;
参考文献
OXFORD GLYCOSCIENCES (UK) LTD
Patent: WO2004/46122 A2, 2004 ;
Location in patent: Page 15 ;
反应条件
nitric acid in chloroform; acetic acid
反应条件
sodium hydrogencarbonate in methanol; toluene
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
反应条件
boron tribromide in dichloromethane T=-70 - 20°C; 4 h;
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
Location in patent: Page/Page column 64 ;
反应条件
1: acetic acid; nitric acid; acetic anhydride / 2 h / -30 - 20 °C 2: boron tribromide / dichloromethane / 4 h / -70 - 20 °C View Scheme
反应条件
1: thionyl chloride / 1.5 h / 0 °C / |Reflux 2: acetic acid; nitric acid; acetic anhydride / 2 h / -30 - 20 °C 3: boron tribromide / dichloromethane / 4 h / -70 - 20 °C View Scheme
反应条件
1: acetic acid; nitric acid / 1 h / 0 °C 2: sulfuric acid / 70 °C / |Reflux View Scheme
参考文献
WO2013/19682 A1, ;
WO 2013/019682 A1
反应条件
in diethyl ether Yield given;
参考文献
Chemistry of Natural Compounds, , vol. 26, # 6 p. 691 - 696
Khimiya Prirodnykh Soedinenii, , # 6 p. 811 - 818
反应条件
potassium carbonate T=20°C;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
Location in patent: Page/Page column 106; 107 ;
WO 2013/019682 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; ethyl acetate 72 h;
参考文献
OXFORD GLYCOSCIENCES (UK) LTD
Patent: WO2004/46122 A2, 2004 ;
Location in patent: Page 15-16 ;
