3-甲基-1,2-苯并异噻唑合成路线 （共 18 条）
反应条件
sulfuric acid; potassium nitrate 1.) 0-5 deg C, 4 h; 2.) 20 deg C, 12 h;
参考文献
Journal of Chemical Research, Miniprint, , # 6 p. 2845 - 2866
反应条件
dihydrogen peroxide; acetic acid T=100°C;
参考文献
Carrington,D.E.L. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3006 - 3010
反应条件
sulfur monochloride in tetrahydrofuran
9 h; Ambient temperature;
参考文献
Buchwald,S.; Watson,B.T.; Lum,R.T.
Journal of the American Chemical Society, 1987 , vol. 109, p. 7137
反应条件
acetic anhydride in pyridine
24 h; Heating;
参考文献
McKinnon, David M.; Lee, Kingsley R.
Canadian Journal of Chemistry, 1988 , vol. 66, p. 1405 - 1409
反应条件
Cu(I) 3-methylsalicylate in N,N-dimethyl-formamide
12 h; Microwave irradiationHeatingInert atmosphereSealed tube;
参考文献
Zhang, Zhihui; Lindale, Matthew G.; Liebeskind, Lanny S.
Journal of the American Chemical Society, 2011 , vol. 133, # 16 p. 6403 - 6410
反应条件
Cu(I) 3-methylsalicylate in N,N-dimethyl-formamide
1 h; Microwave irradiationHeatingInert atmosphereSealed tube;
参考文献
Zhang, Zhihui; Lindale, Matthew G.; Liebeskind, Lanny S.
Journal of the American Chemical Society, 2011 , vol. 133, # 16 p. 6403 - 6410
参考文献
Clarke,K. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 356 - 359
反应条件
1.1: NaH / dimethylformamide
1.2: 54 percent / dimethylformamide / 3 h / Heating
2.1: 60 percent / ethanol / 1.5 h / Heating
3.1: 45 percent / 0.5 h / 650 °C
View Scheme
参考文献
Creed; Leardini; McNab; Nanni; Nicolson; Reed
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 1079 - 1085
反应条件
1: hydroxylamine hydrochloride / ethanol; pyridine / 4 h / Heating
2: 95 percent / acetic anhydride / pyridine / 24 h / Heating
View Scheme
参考文献
McKinnon, David M.; Lee, Kingsley R.
Canadian Journal of Chemistry, 1988 , vol. 66, p. 1405 - 1409
反应条件
1: aq. NaOH / ethanol / Heating
2: 165 °C
View Scheme
参考文献
Carrington,D.E.L. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 3006 - 3010
