顺式-4-羟基-L-脯氨酸合成路线 （共 45 条）
反应条件
1: hydrogenchloride; acetic acid / water / 0.5 h / Reflux 2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Reflux 3: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 20 °C 4: sodium dihydrogenphosphate; sodium chlorite; water / methyl-2-butene; tert-butyl alcohol / 1.5 h / 0 - 20 °C 5: palladium 10 on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr View Scheme
参考文献
Synthetic Communications, , vol. 42, # 9 p. 1278 - 1287
反应条件
1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Reflux 2: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 20 °C 3: sodium dihydrogenphosphate; sodium chlorite; water / methyl-2-butene; tert-butyl alcohol / 1.5 h / 0 - 20 °C 4: palladium 10 on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr View Scheme
参考文献
Synthetic Communications, , vol. 42, # 9 p. 1278 - 1287
反应条件
1: sodium dihydrogenphosphate; sodium chlorite; water / methyl-2-butene; tert-butyl alcohol / 1.5 h / 0 - 20 °C 2: palladium 10 on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr View Scheme
参考文献
Synthetic Communications, , vol. 42, # 9 p. 1278 - 1287
反应条件
1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 20 °C 2: sodium dihydrogenphosphate; sodium chlorite; water / methyl-2-butene; tert-butyl alcohol / 1.5 h / 0 - 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr View Scheme
参考文献
Synthetic Communications, , vol. 42, # 9 p. 1278 - 1287
反应条件
sodium hydroxide 2 h; Yield given;
参考文献
Tetrahedron Asymmetry, , vol. 7, # 3 p. 825 - 830
反应条件
1: NaBH4 2: HBr, AcOH View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 54, # 1-3 p. 195
参考文献
Journal of the Chemical Society, , p. 431
参考文献
Chemische Berichte, , vol. 92, p. 2106,2109
反应条件
acetic acid 0.25 h; Ambient temperature;
参考文献
Papaioannou, Dionissios; Stavropoulos, George; Karagiannis, Kostas; Francis, George W.; Brekke, Trond; Aksnes, Dagfinn W.
Acta Chemica Scandinavica, 1990 , vol. 44, # 3 p. 243 - 251
反应条件
1: aqueous NaOH 2: ueber das Brucin-Salz 3: aqueous HCl View Scheme
参考文献
Chemische Berichte, , vol. 92, p. 2106,2109
