顺式-4-羟基-L-脯氨酸合成路线 （共 45 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr; 4 h;
参考文献
Mereyala, Hari Babu; Pathuri, Gopal; Nagarapu, Lingaiah
Synthetic Communications, 2012 , vol. 42, # 9 p. 1278 - 1287
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 2 h; Ambient temperature;
参考文献
Brown, Allan G.; Moss, Stephen F.; Southgate, Robert
Tetrahedron Letters, 1994 , vol. 35, # 3 p. 451 - 454
反应条件
iron sulphate heptahydrate; cis-4-proline hydroxylase; sodium L-ascorbate T=25°C; 16 h; stereospecific reaction;
参考文献
Klein, Christian; Huettel, Wolfgang
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 1643 - 1647
反应条件
1: 635 g / aq. NaHCO3 / tetrahydrofuran / 17 h / 25 °C 2: 90 percent / SOCl2 / 17 h / 25 °C 3: 1.) DCC, CuCl / 1.) dioxane, 45-50 deg C, 48 h, 2.) toluene, reflux, 24 h 4: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C 5: 496 mg / H2 / Pd-C / H2O / 3 h / 25 °C / 2660 Torr View Scheme
参考文献
Bioscience, Biotechnology, and Biochemistry, , vol. 59, # 6 p. 1161 - 1162
反应条件
1: 90 percent / SOCl2 / 17 h / 25 °C 2: 1.) DCC, CuCl / 1.) dioxane, 45-50 deg C, 48 h, 2.) toluene, reflux, 24 h 3: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C 4: 496 mg / H2 / Pd-C / H2O / 3 h / 25 °C / 2660 Torr View Scheme
参考文献
Bioscience, Biotechnology, and Biochemistry, , vol. 59, # 6 p. 1161 - 1162
反应条件
hydrogenchloride T=140°C; 3 h;
参考文献
Mehlfuehrer, Michaela; Berner, Heinz; Thirring, Klaus
Journal of the Chemical Society, Chemical Communications, 1994 , # 11 p. 1291 - 1292
反应条件
1: iodine / tetrahydrofuran; H2O / 0.5 h / Ambient temperature 2: H2 / Pd(OH)2 / ethanol / 5 h / 1861.7 Torr / Ambient temperature 3: 1M NaOH / 2 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 3 p. 825 - 830
反应条件
1: H2 / Pd(OH)2 / ethanol / 5 h / 1861.7 Torr / Ambient temperature 2: 1M NaOH / 2 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 3 p. 825 - 830
反应条件
1: 1.) EtO2CN=NCOOEt, Ph3P, 2.) aq. NaOH / 1.) HCO2H, THF, from 0 deg C to r.t., 18 h; 2.) 1,4-dioxane, 0 deg C, 0.25 h 2: 68 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 3 p. 451 - 454
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 19 h; 2: With TEA in ethanol
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
