3-氯-7-羟基-4-甲基香豆素合成路线 （共 13 条）
反应条件
trifluoroacetic acid T=100°C; Pechmann condensation; 0.5 h; Microwave irradiation; regioselective reaction;
参考文献
Zak, Jaroslav; Ron, David; Riva, Elena; Harding, Heather P.; Cross, Benedict C. S.; Baxendale, Ian R.
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9901 - 9910
反应条件
aluminum oxide; copper dichloride in chlorobenzene 20 h; Heating;
参考文献
Thapliyal; Singh; Khanna
Synthetic Communications, 1993 , vol. 23, # 20 p. 2821 - 2826
反应条件
aluminum oxide; methanesulfonic acid T=20°C; Pechmann reaction; 0.133333 h;
参考文献
Sharghi, Hashem; Jokar, Mahboubeh
Heterocycles, 2007 , vol. 71, # 12 p. 2721 - 2733
反应条件
sodium perchlorate; cycloplatinated aryl ketoxime in acetonitrile T=25°C; pH=8.5; Kinetics;
参考文献
Russian Chemical Bulletin, , vol. 50, # 10 p. 1844 - 1848
反应条件
ethanol; sulfuric acid
参考文献
Journal of Scientific and Industrial Research, , vol. 11 B, p. 50,55
反应条件
1: acetic acid; tetrachloromethane; chlorine 2: sulfuric acid; ethanol View Scheme
参考文献
Journal of Scientific and Industrial Research, , vol. 11 B, p. 50,55
参考文献
Journal of Scientific and Industrial Research, , vol. 11 B, p. 50,55
反应条件
1: 3-chloro-4-methyl-7-hydroxycoumarin With n-butyllithium in tetrahydrofuran; hexane 1 h; 2: O,O-diethyl chlorothiophosphate in tetrahydrofuran; hexane T=20°C; 12 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 1 p. 246 - 255
反应条件
1: 3-chloro-4-methyl-7-hydroxycoumarin With sodium hydride in tetrahydrofuran 0.5 h; Heating; 2: diethyl chlorophosphate in tetrahydrofuran T=20°C; 12 h;
参考文献
Briseno-Roa, Luis; Hill, Jim; Notman, Stuart; Sellers, David; Smith, Andy P.; Timperley, Christopher M.; Wetherell, Janet; Williams, Nichola H.; Williams, Gareth R.; Fersht, Alan R.; Griffiths, Andrew D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 246 - 255
反应条件
1: 79 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 4 h / Heating 2: 95 percent / neat (no solvent) / 0.25 h / 190 - 210 °C View Scheme
参考文献
Phillips, Lawrence R.; Supko, Jeffrey G.; Wolfe, Tracy L.; Malspeis, Louis
Synthetic Communications, 1996 , vol. 26, # 9 p. 1805 - 1814
