(3-硝基苯甲酰基氨基)-乙酸合成路线 （共 8 条）
反应条件
aniline; palladium in diethyl ether; ethanol; acetonitrile
参考文献
G.D. SEARLE and CO.
Patent: EP850221 B1, 2001 ;
反应条件
hydrogenchloride; potassium hydroxide in water; acetonitrile
参考文献
G.D. SEARLE and CO.
Patent: EP850221 B1, 2001 ;
参考文献
Saunders; Stacey; Wilding
Biochemical Journal, 1942 , vol. 36, p. 368,374
反应条件
1: (COCl)2, DMF / benzene / Ambient temperature
2: NaOH / H2O / 70 - 80 °C
View Scheme
参考文献
DeRuiter, Jack; Swearingen, Blake E.; Wandrekar, Vinay; Mayfield, Charles A.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1033 - 1038
反应条件
hydroxide
T=25°C; pH dependence; Rate constant;
参考文献
Curran, Terence C; Farrar, Charles R.; Niazy, Omima; Williams, Andrew
Journal of the American Chemical Society, 1980 , vol. 102, # 22 p. 6828 - 6837
反应条件
sulfuric acid; nitric acid
参考文献
Schwanert
Justus Liebigs Annalen der Chemie, 1859 , vol. 112, p. 66
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Conrad
Journal fuer Praktische Chemie (Leipzig), 1877 , vol. <2> 15, p. 254
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Bertagnini
Justus Liebigs Annalen der Chemie, 1851 , vol. 78, p. 109
参考文献
Klages; Haack
Chemische Berichte, 1903 , vol. 36, p. 1648
参考文献
Miyatake; Kaga
Yakugaku Zasshi, 1952 , vol. 72, p. 627
Chem.Abstr., 1953 , p. 2734
