2-(6-苄基巯基嘌呤-9-基)-5-(羟基甲基)四氢呋喃-3,4-二醇合成路线 （共 9 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; Substitution; 40 h;
参考文献
Lin, Xiaoyu; Robins, Morris J.
Organic Letters, 2000 , vol. 2, # 22 p. 3497 - 3499
反应条件
formic acid in water; ethyl acetate
参考文献
ICN Pharmaceuticals, Inc.
Patent: US3948886 A1, 1976 ;
US 3948886 A
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Fleming, Steven A.; Rawlins, David B.; Samano, Vicente; Robins, Morris J.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5968 - 5976
反应条件
potassium carbonate in ethanol
T=100°C; 0.166667 h; Microwave irradiation;
参考文献
Niu, Hong-Ying; Xia, Chao; Qu, Gui-Rong; Wu, Shan; Jiang, Yi; Jin, Xin; Guo, Hai-Ming
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 45 - 49
反应条件
1: I2; PPh3; EtN(i-Pr)2 / toluene / 0.83 h / 95 °C
2: 141 mg / NH3 / methanol / 2 h / 0 °C
3: 92 percent / NaH / dimethylformamide; various solvent(s) / 40 h / 20 °C
View Scheme
参考文献
Lin, Xiaoyu; Robins, Morris J.
Organic Letters, 2000 , vol. 2, # 22 p. 3497 - 3499
反应条件
1: 141 mg / NH3 / methanol / 2 h / 0 °C
2: 92 percent / NaH / dimethylformamide; various solvent(s) / 40 h / 20 °C
View Scheme
参考文献
Lin, Xiaoyu; Robins, Morris J.
Organic Letters, 2000 , vol. 2, # 22 p. 3497 - 3499
参考文献
Johnson et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 699,702
反应条件
1: ethanol / 1 h / 100 °C / Microwave irradiation
2: potassium carbonate / ethanol / 0.17 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Niu, Hong-Ying; Xia, Chao; Qu, Gui-Rong; Wu, Shan; Jiang, Yi; Jin, Xin; Guo, Hai-Ming
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 45 - 49
反应条件
triethylamine
T=60 - 90°C; 18 h;
参考文献
Alvarez, Zadkiel; Lee, Kyungae; Abel-Santos, Ernesto
Antimicrobial Agents and Chemotherapy, 2010 , vol. 54, # 12 p. 5329 - 5336
