吡嗪-2,3-二羧酸 二甲酯合成路线 （共 10 条）
反应条件
ammonia in methanol Heating;
参考文献
Tsuda, Tadataka; Fujishima, Katsuhiro; Ueda, Hiroo
Agricultural and Biological Chemistry, 1981 , vol. 45, # 9 p. 2129 - 2130
参考文献
Paul,D.B.
Australian Journal of Chemistry, 1974 , vol. 27, p. 1331 - 1339
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Jones
Journal of the American Chemical Society, 1956 , vol. 78, p. 159,161, 162
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Yale et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 1933,1934
反应条件
hydrogenchloride in isopropyl alcohol
24 h; Heating;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2004/96807 A2, 2004 ;
Location in patent: Page 57; 60 ;
反应条件
sulfuric acid in methanol; ethyl acetate
参考文献
Nycomed Imaging AS
Patent: US5972926 A1, 1999 ;
反应条件
ethanol
T=125°C; anschliessend mit Methanol und konz. H2SO4;
参考文献
Ellingson; Henry
Journal of the American Chemical Society, 1949 , vol. 71, p. 2798
反应条件
1: aqueous HBr; bromine / folgendes Behandeln mit NaNO2
2: aqueous ethanol / 125 °C / anschliessend mit Methanol und konz. H2SO4
View Scheme
参考文献
Ellingson; Henry
Journal of the American Chemical Society, 1949 , vol. 71, p. 2798
反应条件
2: SOCl2
View Scheme
参考文献
Solomons; Spoerri
Journal of the American Chemical Society, 1953 , vol. 75, p. 679
反应条件
1: SOCl2
View Scheme
参考文献
Solomons; Spoerri
Journal of the American Chemical Society, 1953 , vol. 75, p. 679
参考文献
Solomons; Spoerri
Journal of the American Chemical Society, 1953 , vol. 75, p. 679
反应条件
1: 83.3 percent / NH3 / methanol / Heating
2: 65 percent / Heating
View Scheme
参考文献
Gabriel; Sonn
Chemische Berichte, 1907 , vol. 40, p. 4852
