2-甲氧基-6-甲基苯甲酸合成路线 （共 45 条）
反应条件
1: With sodium hydroxide; water in ethanol 24 h; Heating / reflux; 2: With hydrogenchloride in water pH=4;
参考文献
RESVERLOGIX CORP.; JOHANSSON, Jan, O.; HANSEN, Henrik, C.; CHIACCHIA, Fabrizio, S.; WONG, Norman, C.W.
Patent: WO2007/16525 A2, 2007 ;
Location in patent: Page/Page column 108-112 ;
WO 2007/016525 A2
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran T=-78 - 20°C;
参考文献
Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3419 - 3429
反应条件
sodium chlorite; aminosulfonic acid in tetrahydrofuran; water 1 h; Ambient temperature;
参考文献
Hauser, Frank M.; Ellenberger, Suzanne R.
Synthesis, 1987 , # 8 p. 723 - 724
反应条件
nitrosyl-sulphuric acid; water in dichloromethane Ambient temperature;
参考文献
Fisher, Lawrence E.; Muchowski, Joseph M.; Clark, Robin D.
Journal of Organic Chemistry, 1992 , vol. 57, # 9 p. 2700 - 2705
反应条件
1: iso-butyllithium; ortho-methoxybenzoic acid With (E)-1,2-Bis(dimethylamino)-ethylen in tetrahydrofuran T=-78°C; 2 h; 2: methyl iodide in tetrahydrofuran T=-78 - 20°C;
参考文献
Organic Letters, , vol. 8, # 4 p. 765 - 768
反应条件
1: ortho-methoxybenzoic acid With n-butyllithium; potassium tert-butylate in tetrahydrofuran T=-78°C; 2 h; 2: methyl iodide in tetrahydrofuran T=-78 - 20°C;
参考文献
Organic Letters, , vol. 8, # 4 p. 765 - 768
反应条件
pyridine; potassium permanganate; dipotassium peroxodisulfate; tetra-(n-butyl)ammonium iodide; copper(II) sulfate 1.) H2O, acetonitrile, 66-69 deg C, 3 h, 2.) benzene, water, 34-35 deg C, 150 min; Yield given. Multistep reaction;
参考文献
Synthesis, , # 12 p. 1000 - 1002
反应条件
1: 1.) AgNO3, NaHCO3, 2.) triethylamine / 1.) DMSO, room temp, 1 h, 2.) 15 min 2: n-bromosuccinimide / azobisisobutyronitrile / CCl4 / 0.5 h / Heating; Irradiation View Scheme
参考文献
Synthesis, , # 6 p. 504 - 506
反应条件
1: K2CO3 / acetone / 12 h / Heating 2: 10percent aq. NaOH / ethanol / 24 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 25, p. 796 - 798
参考文献
Bulletin de la Societe Scientifique de Bretagne, , vol. 31, p. Sonderheft S.9,41
