4-羟基-3-硝基苯甲酸合成路线 （共 85 条）
反应条件
1: sulfuric acid / 12 h / |Inert atmosphere; |Schlenk technique; |Reflux
2: palladium 10 on activated carbon; hydrogen / methanol / |Inert atmosphere; |Schlenk technique
3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-diethylaniline / N,N-dimethyl-formamide / 20 °C / |Inert atmosphere; |Schlenk technique
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参考文献
Nakamura, Hiroyuki; Yasui, Yuka; Ban, Hyun Seung
Journal of Organometallic Chemistry, 2013 , vol. 747, p. 189 - 194
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 72 h; Inert atmosphere;
参考文献
AKAAL PHARMA PTY LTD; GROBELNY, Damian W; GILL, Gurmit S
Patent: WO2014/63199 A1, 2014 ;
Location in patent: Page/Page column 54 ;
反应条件
sulfuric acid
T=85 - 90°C; 4 h;
参考文献
Tee, Oswald S.; Du, Xian-Xian
Journal of the American Chemical Society, 1992 , vol. 114, # 2 p. 620 - 627
反应条件
potassium carbonate; xylene
Erwaermen des Reaktionsprodukts mit wss.-aethanol. NaOH;
参考文献
Clinton et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 592,595
反应条件
1: H2SO4
2: K2CO3; KI / dimethylformamide
3: aq. NaOH / ethanol
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参考文献
Prasad, Veena; Rao, D. S. Shankar; Prasad, S. Krishna
Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 2003 , vol. 397, p. 79 - 88
