(Z)-3-甲基戊-2-烯-4-炔-1-醇合成路线 （共 32 条）
反应条件
1: 75 percent / H2 / Lindlar catalyst / ethanol 2: 60 percent / NCS; dimethyl sulfide / CH2Cl2 / -40 - 0 °C View Scheme
参考文献
Wu, Zheng; Wouters, Johan; Poulter, C. Dale
Journal of the American Chemical Society, 2005 , vol. 127, # 49 p. 17433 - 17438
反应条件
sulfuric acid; hydroquinone; mercury dichloride in di-isopropyl ether T=50 - 52°C; 0.166667 h; Product distribution;
参考文献
Zacharias; Pushpakumari; Sreevalsan; Pillai
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 1 p. 59 - 62
反应条件
1: 98 percent / CuCl2*2H2O 2: 1.) phosphorus oxychloride / 1.) 25 deg C, 1 h, 2.) a) RT, 2 h, b) 60-80 deg C, 15 min 3: 92 percent / silver oxide / 0.5 h View Scheme
参考文献
Vegh, Daniel; Zalupsky, Peter; Kovac, Jaroslav
Synthetic Communications, 1990 , vol. 20, # 8 p. 1113 - 1123
参考文献
Schwieter,U. et al.
Helvetica Chimica Acta, 1962 , vol. 45, p. 517 - 528
反应条件
1: 81 percent / PPh3; DEAD / tetrahydrofuran / 2 h / 0 - 20 °C 2: 46 percent / LiAlH4 / diethyl ether / 0.5 h / 20 °C 3: 36 percent / KI / PdI2 / 2 h / 100 °C View Scheme
参考文献
Gabriele, Bartolo; Salerno, Giuseppe; Fazio, Alessia
Organic Letters, 2000 , vol. 2, # 3 p. 351 - 352
反应条件
2: Pd(PPh3)4; TlOH / H2O; tetrahydrofuran / 6 h / 25 °C 3: 91 percent / KOH / ethanol; H2O / 70 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
反应条件
1: 98 percent / CuCl2*2H2O 2: 1.) phosphorus oxychloride / 1.) 25 deg C, 1 h, 2.) a) RT, 2 h, b) 60-80 deg C, 15 min View Scheme
参考文献
Vegh, Daniel; Zalupsky, Peter; Kovac, Jaroslav
Synthetic Communications, 1990 , vol. 20, # 8 p. 1113 - 1123
反应条件
1: 98 percent / CuCl2*2H2O 2: 1.) phosphorus oxychloride / 1.) 25 deg C, 1 h, 2.) a) RT, 2 h, b) 60-80 deg C, 15 min 3: 89 percent / pyridine / 5 h / 100 °C View Scheme
参考文献
Vegh, Daniel; Zalupsky, Peter; Kovac, Jaroslav
Synthetic Communications, 1990 , vol. 20, # 8 p. 1113 - 1123
参考文献
Istrate, Florin M.; Gagosz, Fabien
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 878 - 885
反应条件
1: MnO2 / CH2Cl2 / 3 h / Ambient temperature 2: TsOH / CH2Cl2 / 1.5 h / Ambient temperature 3: 1.) 1.5 M BuLi, 2.) 3.5 M natrium-dihydro-bis(2-methoxyethoxy)aluminate, 3.) H2O, pyridinium p-toluenesulfonate / 1.) THF/hexane, -15 deg C, 15 min, 2.) THF/hexane/toluene, -45 deg C, 1 h, 3.) THF, 2 h, room temperature 4: 21.9 g / MnO2 / CH2Cl2 / 2 h / Ambient temperature 5: NaClO2, NaH2PO4*2H2O / 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature View Scheme
参考文献
Soukup, Milan; Lukac, Teodor; Lohri, Bruno; Widmer, Erich
Helvetica Chimica Acta, 1989 , vol. 72, p. 361 - 364
