2-氨基-5-羟基-戊酸合成路线 （共 11 条）
反应条件
1: With NosE gene from Escherichia coli; nicotinamide adenine dinucleotide; anhydrous zinc sulfate; glycine in water T=42°C; pH=10; 5 h; 2: With NosF gene from Escherichia coli in water pH=10; 0.25 h; Further stages.;
参考文献
Luesch, Hendrik; Hoffmann, Dietmar; Hevel, Joan M.; Becker, Julia E.; Golakoti, Trimurtulu; Moore, Richard E.
Journal of Organic Chemistry, 2003 , vol. 68, # 1 p. 83 - 91
反应条件
1: With trifluoroacetic acid in dichloromethane
T=20°C;
2: With Dowex-50W resin [H(+)-form] in water
Further stages.;
参考文献
Luesch, Hendrik; Hoffmann, Dietmar; Hevel, Joan M.; Becker, Julia E.; Golakoti, Trimurtulu; Moore, Richard E.
Journal of Organic Chemistry, 2003 , vol. 68, # 1 p. 83 - 91
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=4°C; 2 h;
2: With water; acetic acid
T=20°C; 24 h;
参考文献
Hannachi, Jean-Christophe; Vidal, Joelle; Mulatier, Jean-Christophe; Collet, Andre
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2367 - 2373
反应条件
lithium borohydride in tetrahydrofuran
2 h; Heating;
参考文献
Rosenthal, Gerald A.; Dahlman, D. L.; Crooks, Peter A.; Phuket, Supinan Na; Trifonov, L. S.
Journal of Agricultural and Food Chemistry, 1995 , vol. 43, # 10 p. 2728 - 2734
反应条件
potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I
T=40°C; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;
参考文献
Chenault, H. Keith; Dahmer, Juergen; Whitesides, George M.
Journal of the American Chemical Society, 1989 , vol. 111, # 16 p. 6354 - 6364
反应条件
formic acid
T=20°C; 4 h;
参考文献
Kisugi, Takaya; Okino, Tatsufumi
Journal of Natural Products, 2009 , vol. 72, # 4 p. 777 - 781
反应条件
1: 92 percent / 1,2-dimethoxy-ethane; tetrahydrofuran / 48 h / Heating
2: BH3 / tetrahydrofuran; 1,2-dimethoxy-ethane / 24 h / 0 - 20 °C
3: 1.5 M aq. HCl / 0.75 h / Heating
View Scheme
参考文献
Garcia, Monica; Serra, Anna; Rubiralta, Mario; Diez, Anna; Segarra, Victor; Lozoya, Estrella; Ryder, Hamish; Palacios, Jose M.
Tetrahedron Asymmetry, 2000 , vol. 11, # 4 p. 991 - 994
反应条件
1: BH3 / tetrahydrofuran; 1,2-dimethoxy-ethane / 24 h / 0 - 20 °C
2: 1.5 M aq. HCl / 0.75 h / Heating
View Scheme
参考文献
Garcia, Monica; Serra, Anna; Rubiralta, Mario; Diez, Anna; Segarra, Victor; Lozoya, Estrella; Ryder, Hamish; Palacios, Jose M.
Tetrahedron Asymmetry, 2000 , vol. 11, # 4 p. 991 - 994
反应条件
1: With lithium borohydride in tetrahydrofuran
Inert atmosphereReflux;
2: With water; acetic acid in tetrahydrofuran; methanol
pH=5; Cooling with ice;
参考文献
Carmo-Silva, Ana E.; Keys, Alfred J.; Beale, Michael H.; Ward, Jane L.; Baker, John M.; Hawkins, Nathaniel D.; Arrabaca, Maria Celeste; Parry, Martin A.J.
Phytochemistry, 2009 , vol. 70, # 5 p. 664 - 671
反应条件
hydrogenchloride; sodium nitrite in water
24 h; Ambient temperatureNaNO2: 1 equivalent;
参考文献
Gouesnard, Jean-Paul
Bulletin de la Societe Chimique de France, 1989 , # 1 p. 88 - 94
