乙酰丙酮酸乙酯合成路线

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/32667 A1, 2009 ;
Location in patent: Page/Page column 135-135 ;
WO 2009/032667 A1

615-79-2乙酰丙酮酸乙酯

218632-36-11-(4-甲氧基苯基)-3-甲基-1H-吡唑-5-羧酸乙酯

参考文献

Pruitt, James R.; Pinto, Donald J. P.; Galemmo Jr., Robert A.; Alexander, Richard S.; Rossi, Karen A.; Wells, Brian L.; Drummond, Spencer; Bostrom, Lori L.; Burdick, Debra; Bruckner, Robert; Chen, Haiying; Smallwood, Angela; Wong, Pancras C.; Wright, Matthew R.; Bai, Steven; Luettgen, Joseph M.; Knabb, Robert M.; Lam, Patrick Y. S.; Wexler, Ruth R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5298 - 5315

615-79-2乙酰丙酮酸乙酯+

3471-32-7

218632-36-11-(4-甲氧基苯基)-3-甲基-1H-吡唑-5-羧酸乙酯

参考文献

Hu, Jun; Wang, Jikui; Zhou, Taoyu; Xu, Yanhua
Journal of Chemical Research, 2011 , vol. 35, # 9 p. 525 - 527

19501-58-74-甲氧基苯肼盐酸盐+

615-79-2乙酰丙酮酸乙酯

126068-76-61-(4-甲氧基-苯基)-5-甲基-1H-吡唑-3-羧酸乙酯+

218632-36-11-(4-甲氧基苯基)-3-甲基-1H-吡唑-5-羧酸乙酯

参考文献

Athersys, Inc.
Patent: US2007/197526 A1, 2007 ;
Location in patent: Page/Page column 14; 15; 26; 27 ;
US 20070197526 A1

615-79-2乙酰丙酮酸乙酯

102082-85-9+

141-97-9乙酰乙酸乙酯

参考文献

Mumm; Hueneke
Chemische Berichte, 1917 , vol. 50, p. 1573

615-79-2乙酰丙酮酸乙酯

144-62-7草酸+

78-98-8丙酮醛

参考文献

Schreiber; Herold
Chemische Berichte, 1913 , vol. 46, p. 1108
Justus Liebigs Annalen der Chemie, 1914 , vol. 405, p. 315

823-85-84-氟苯肼盐酸盐+

615-79-2乙酰丙酮酸乙酯

126129-41-7+

288251-64-91-(4-氟苯基)-3-甲基-1H-吡唑-5-羧酸乙酯

参考文献

3M INNOVATIVE PROPERTIES COMPANY
Patent: WO2007/79086 A1, 2007 ;
Location in patent: Page/Page column 83 ;

371-14-24-氟苯肼+

615-79-2乙酰丙酮酸乙酯

288251-64-91-(4-氟苯基)-3-甲基-1H-吡唑-5-羧酸乙酯

参考文献

Hu, Jun; Wang, Jikui; Zhou, Taoyu; Xu, Yanhua
Journal of Chemical Research, 2011 , vol. 35, # 9 p. 525 - 527

371-14-24-氟苯肼+

615-79-2乙酰丙酮酸乙酯

126129-41-7+

288251-64-91-(4-氟苯基)-3-甲基-1H-吡唑-5-羧酸乙酯

参考文献

Mitsubishi Pharma Corporation
Patent: EP1176140 A1, 2002 ;
Location in patent: Page 48 ;

20207-16-32-氨基-3-氧代-丁酸乙酯盐酸盐+

615-79-2乙酰丙酮酸乙酯

29170-87-43-甲基-吡咯-2,5-二羧酸二乙酯+

21898-53-3

参考文献

Kondo; Ohno
Yakugaku Zasshi, 1934 , vol. 54, p. 683,687; dtsch. Ref. S. 123
Chem.Abstr., 1937 , p. 103
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Kondo; Ohno; Sato
Yakugaku Zasshi, 1937 , vol. 57, p. 3; dtsch. Ref. S. 1, 3
Chem.Abstr., 1937 , p. 7055