3-(2-呋喃基)-3-氧代丙酸乙酯合成路线 （共 26 条）
反应条件
sodium hydride in tetrahydrofuran T=70°C; 1 h;
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP946508 B1, 2009 ;
Location in patent: Page/Page column 106 ;
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile T=10 - 20°C; 2: furan-2-carbonyl chloride in acetonitrile T=0 - 20°C; 3: With hydrogenchloride in water; toluene T=0 - 5°C; 0.25 h;
参考文献
F2G LTD
Patent: WO2009/130481 A1, 2009 ;
Location in patent: Page/Page column 79-80 ;
反应条件
sodium methylate; benzene
参考文献
Journal of the American Chemical Society, , vol. 73, p. 5857
反应条件
molybdenium(VI) dioxodichloride in dichloromethane T=20°C; 5 h;
参考文献
Jeyakumar, Kandasamy; Chand, Dillip Kumar
Synthesis, 2008 , # 11 p. 1685 - 1687
反应条件
samarium; iodine in tetrahydrofuran 2 h; Heating;
参考文献
Zou, Xuefei; Jia, Xiaofei; Wang, Xiaoxia; Xie, Guanqun
Synthetic Communications, 2007 , vol. 37, # 10 p. 1617 - 1625
反应条件
1: ethyl acetate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: furan-2-carbonyl chloride in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere;
参考文献
Sridhar; Srihari
European Journal of Organic Chemistry, 2013 , # 3 p. 578 - 587
反应条件
tetrafluoroboric acid diethyl ether complex in dichloromethane T=-78°C; 14 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 22 p. 7599 - 7608
反应条件
sodium hydroxide in hexane 1 h; Ambient temperature;
参考文献
Sato, Nobuhiro; Saito, Noriko
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1737 - 1740
反应条件
in tetrahydrofuran; mineral oil
参考文献
DuPont Pharmaceuticals Company
Patent: US6020357 A1, 2000 ;
US 6020357 A
反应条件
1: polystyrene-supported α-seleno acetate, loading 1.64 mmol/g (COOH) With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: furfural in tetrahydrofuran T=-78 - 20°C; 2.5 h; 3: With dihydrogen peroxide in tetrahydrofuran T=20°C;
参考文献
Synlett, , # 10 p. 1547 - 1548
