PFIZER MANUFACTURING IRELAND; BURRELL, Adam James Musgrave; MARTINEZ, Carlos Alberto; MCDAID, Paul Oliver; O'NEILL, Padraig Mary; WONG, John Wing
Patent: WO2012/25861 A1, 2012 ;
Location in patent: Page/Page column 20 ;
WO 2012/025861 A1
1: malonic acid ethyl ester monopotassium salt With magnesium chloride in acetonitrile T=35°C; 0.75 h; 2: With triethylamine in acetonitrile T=25°C; 0.5 h; 3: 1-(3-fluorobenzoyl) imidazole With hydrogenchloride; water more than 3 stages;
参考文献
Ouellet, Stephane G.; Gauvreau, Danny; Cameron, Mark; Dolman, Sarah; Campeau, Louis-Charles; Hughes, Gregory; O'Shea, Paul D.; Davies, Ian W.
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 214 - 219
1: butyric acid With 1,1'-carbonyldiimidazole in tetrahydrofuran Acylation; 2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran Substitution; decarboxylation;
参考文献
Liu, Bo; Liu, Gang; Xin, Zhili; Serby, Micheal D.; Zhao, Hongyu; Schaefer, Verlyn G.; Falls, H. Douglas; Kaszubska, Wiweka; Collins, Christine A.; Sham, Hing L.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 20 p. 5223 - 5226
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in tetrahydrofuran T=0 - 20°C; 2: bromobenzoic acid chloride in tetrahydrofuran T=0 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; water T=20°C;
参考文献
Reddy, C. Naveenkumar; Subbaraju, Gottumukkala V.; Mohan, H. Rama; Rao, D. Muralimohan
Asian Journal of Chemistry, 2011 , vol. 23, # 7 p. 2981 - 2988
