3-(4-甲氧基苯基)-5-甲基异噁唑合成路线 （共 17 条）
反应条件
5 Pd(II)/C(eggshell); hydrogen in ethyl acetate
T=20°C; P=760.051 Torr; 3 h;
参考文献
Yermolina, Maria V.; Wang, Jizhen; Caffrey, Michael; Rong, Lijun L.; Wardrop, Duncan J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 765 - 781
反应条件
hydroxylamine hydrochloride; sodium acetate in methanol
6 h; Ambient temperature;
参考文献
Akhtar, M. Shamim; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, p. 71 - 72
反应条件
1: propargyl bromide With iodine; magnesium; mercury dichloride in tetrahydrofuran; toluene
T=20°C; 2 h;
2: 4-methoxybenzonitrile N-oxide in tetrahydrofuran; toluene
6 h;
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
反应条件
1.1: triethylamine / tetrahydrofuran / 0.17 h / 0 - 5 °C
2.1: indium / tetrahydrofuran; H2O; toluene / 3 h
2.2: tetrahydrofuran; H2O; toluene / 22 h
View Scheme
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
1.2: 1 h / 0 - 20 °C
2.1: hydroxylamine hydrochloride; Ba(OH)2 / ethanol / |Reflux
View Scheme
参考文献
Raghava, Byregowda; Parameshwarappa, Gangajji; Acharya, Anand; Swaroop, Toreshettahally R.; Rangappa, Kanchugarakoppal S.; Ila, Hiriyakkanavar
European Journal of Organic Chemistry, 2014 , vol. 2014, # 9 p. 1882 - 1892
反应条件
1: CH3I; NaI / dimethylformamide / 20 h / 80 °C
2: DBU / tetrahydrofuran; dimethylformamide / 10 h / 90 °C
View Scheme
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1: NCS / 3 h / 20 °C
2: 86 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
3: CH3I; NaI / dimethylformamide / 20 h / 80 °C
4: DBU / tetrahydrofuran; dimethylformamide / 10 h / 90 °C
View Scheme
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1: 86 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
2: CH3I; NaI / dimethylformamide / 20 h / 80 °C
3: DBU / tetrahydrofuran; dimethylformamide / 10 h / 90 °C
View Scheme
参考文献
Xu, Wei Ming; Tang; Huang, Xian
Tetrahedron, 2005 , vol. 61, # 2 p. 501 - 506
反应条件
1: propargyl bromide With indium in tetrahydrofuran; water; toluene
3 h;
2: 4-methoxybenzonitrile N-oxide in tetrahydrofuran; water; toluene
22 h;
参考文献
Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender
Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
反应条件
1.1: chloramine-T / water; tert-butyl alcohol / 20 °C
1.2: 20 °C
2.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere
3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
4.1: triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere
6.1: 5 Pd(II)/C(eggshell); hydrogen / ethyl acetate / 3 h / 20 °C
View Scheme
参考文献
Yermolina, Maria V.; Wang, Jizhen; Caffrey, Michael; Rong, Lijun L.; Wardrop, Duncan J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 765 - 781
