2-氧代-3-(3,4,5-三甲氧基苯基)丙酸合成路线 （共 12 条）
反应条件
1: hydroxylamine hydrochloride / aq. NaOH / 0.5 h / 60 °C 2: acetic anhydride / 0.08 h / Heating 3: ZnCl2, HCl / diethyl ether / 5 h / 0 °C 4: 2.0 g / aq. potassium persulphate / aq. KOH / Ambient temperature 5: K2CO3 / acetone / 50 h / Heating 6: 1) Na, 2) conc.hydrochloric acid / 1) r.t., 2) heating, 15-20 min. View Scheme
参考文献
Shaw; Srivastava; Jha
Journal of the Indian Chemical Society, 1990 , vol. 67, # 2 p. 144 - 147
反应条件
sodium hydroxide; dihydrogen peroxide
参考文献
Mauthner
Chemische Berichte, 1908 , vol. 41, p. 3664
Full Text Show Details
Mauthner
Justus Liebigs Annalen der Chemie, 1909 , vol. 370, p. 374
参考文献
Mauthner
Chemische Berichte, 1908 , vol. 41, p. 3664
反应条件
1: hydroxylamine hydrochloride / aq. NaOH / 0.5 h / 60 °C 2: acetic anhydride / 0.08 h / Heating View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 67, # 2 p. 144 - 147
反应条件
1: Ac2O, AcONa / 4 h / 100 °C
2: 1.) 1.0 N aq. NaOH, 2.) aq. HCl / 1.) steam bath, 2.) reflux, 4 h
View Scheme
参考文献
Audia, James E.; Evrard, Deborah A.; Murdoch, Gwyn R.; Droste, James J.; Nissen, Jeffrey S.; Schenck, Kathy W.; Fludzinski, Pawel; Lucaites, Virginia L.; Nelson, David L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2773 - 2780
反应条件
sodium hydroxide in water
Heating;
参考文献
Shaw; Srivastava; Jha
Journal of the Indian Chemical Society, 1990 , vol. 67, # 2 p. 144 - 147
反应条件
hydrogenchloride; sodium hydroxide
1.) steam bath, 2.) reflux, 4 h; Multistep reaction;
参考文献
Audia, James E.; Evrard, Deborah A.; Murdoch, Gwyn R.; Droste, James J.; Nissen, Jeffrey S.; Schenck, Kathy W.; Fludzinski, Pawel; Lucaites, Virginia L.; Nelson, David L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2773 - 2780
反应条件
1: pyridinium chlorochromate / CH2Cl2 / 3 h
2: sodium acetate / acetic anhydride / Heating
3: NaOH / H2O / Heating
View Scheme
参考文献
Shaw; Srivastava; Jha
Journal of the Indian Chemical Society, 1990 , vol. 67, # 2 p. 144 - 147
反应条件
1: lithium aluminium hydride / diethyl ether / 3 h / Heating
2: pyridinium chlorochromate / CH2Cl2 / 3 h
3: sodium acetate / acetic anhydride / Heating
4: NaOH / H2O / Heating
View Scheme
参考文献
Shaw; Srivastava; Jha
Journal of the Indian Chemical Society, 1990 , vol. 67, # 2 p. 144 - 147
反应条件
hydrogenchloride; acetone
参考文献
Michalsky; Sadilek
Monatshefte fuer Chemie, 1959 , vol. 90, p. 171,176
