2'-溴-4'-甲基乙酰苯胺合成路线 （共 38 条）
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 78 percent / BuLi / tetrahydrofuran; hexane / 12 h / Ambient temperature
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 84 percent / 2 h / Heating
4: 63 percent / BuLi / tetrahydrofuran; hexane / -75 °C
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
1: 84 percent / tri-o-tolylphosphine, triethylamine / palladium(ii) acetate / acetonitrile / 24 h / 120 °C / 22800 Torr
2: 55 percent / oxygen / palladium(II) chloride, copper(I) chloride / 1,2-dimethoxy-ethane / 760 Torr
View Scheme
参考文献
Kasahara, Akira; Izumi, Taeko; Murakami, Satoshi; Miyamoto, Kazuhiro; Hino, Toshimi
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1405 - 1413
反应条件
copper oxide; caesium carbonate in dimethyl sulfoxide
T=110°C; 16 h;
参考文献
Saha, Prasenjit; Ali, Md Ashif; Punniyamurthy, Tharmalingam
Organic Syntheses, 2012 , vol. 88, p. 398 - 405
反应条件
caesium carbonate; copper(I) bromide in dimethyl sulfoxide
T=90 - 120°C; 72 h;
参考文献
Yang, Daoshan; Fu, Hua; Hu, Liming; Jiang, Yuyang; Zhao, Yufen
Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7841 - 7844
参考文献
Claus; Steinberg
Chemische Berichte, 1883 , vol. 16, p. 913 Anm.
反应条件
1: 85 percent / NiCl2 / 180 - 190 °C
2: 51 percent / LiAlH4 / diethyl ether / 24 h / 15 - 20 °C
View Scheme
参考文献
Heinicke, Joachim; Gupta, Nidhi; Surana, Anushka; Peulecke, Normen; Witt, Brigitte; Steinhauser, Kinga; Bansal, Raj K; Jones, Peter G
Tetrahedron, 2001 , vol. 57, # 50 p. 9963 - 9972
反应条件
1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; acetonitrile / 6 h / 100 °C / Inert atmosphere
2: PhI(OCH2CF3)2 / 2,2,2-trifluoroethanol / 48 h / Inert atmosphere; Molecular sieve
3: water; potassium hydroxide / methanol / 18 h / 80 °C / Inert atmosphere
View Scheme
参考文献
Kajiyama, Daichi; Inoue, Keisuke; Ishikawa, Yuichi; Nishiyama, Shigeru
Tetrahedron, 2010 , vol. 66, # 52 p. 9779 - 9784
