反应条件
1.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere
1.2: 2 h / -98 - -60 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551