2-氨基-5-苯基噻吩-3-甲酸甲酯合成路线 （共 5 条）
反应条件
sulfur; N-ethyl-N,N-diisopropylamine in DMF (N,N-dimethyl-formamide) T=18 - 25°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/66163 A2, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/066163 A2
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane T=20°C; 4 h;
参考文献
Gopinath, Purushothaman; Chandrasekaran, Srinivasan
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 700 - 703
反应条件
sulfur; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 14 p. 4242 - 4248
反应条件
1: [BnEt3N]2MoS4 / methanol / 0.83 h / 20 °C 2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 4 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 2 p. 700 - 703
反应条件
1: With sodium hydroxide; water in methanol 2 h; Heating / reflux; 2: With hydrogenchloride; water in methanol pH=3 - 5;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/66163 A2, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/066163 A2
