2-氨基-5-溴-噻唑氢溴酸盐合成路线 （共 13 条）
反应条件
pyridine T=25°C; 2 h; Inert atmosphere;
参考文献
Sleebs, Brad E.; Street, Ian P.; Bu, Xian; Baell, Jonathan B.
Synthesis, 2010 , # 7 art. no. P16009SS, p. 1091 - 1096
反应条件
triethylamine in dichloromethane 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/2181 A2, 2007 ;
Location in patent: Page/Page column 128-129 ;
WO 2007/002181 A2
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
NOVO NORDISK A/S
Patent: WO2006/58923 A1, 2006 ;
Location in patent: Page/Page column 51 ;
WO 2006/058923 A1
反应条件
1: With triethylamine in dichloromethane T=0 - 20°C; 18.5 h; 2: With sodium hydroxide in dichloromethane; water pH=8;
参考文献
GALDERMA RESEARCH and DEVELOPMENT, S.N.C.
Patent: WO2004/113331 A1, 2004 ;
Location in patent: Page 60 ;
反应条件
1: 2-amino-5-bromothiazole monohydrobromide With sodium hydrogencarbonate in isopropyl alcohol Industry scale; 2: 2-(pyrrolidin-1-yl)ethanethiol in isopropyl alcohol T=60 - 70°C; 97.25 h; Industry scale;
参考文献
Bueno Melendo, Ana Belen; Agejas-Chicharro, Francisco Javier
Patent: US2010/160395 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
1: in methanol T=20°C; 18 h; 2: With sodium hydroxide in methanol; water pH=12;
参考文献
US2008/21052 A1, ;
Page/Page column 25 ;
US 20080021052 A1
反应条件
sodium hydroxide in water; toluene
参考文献
Bristol-Myers Squibb Company
Patent: US6515004 B1, 2003 ;
US 6515004 B1
反应条件
sodium hydroxide in water; toluene
参考文献
Bristol-Myers Squibb Company
Patent: US6214852 B1, 2001 ;
US 6214852 B1
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 3.25 h;
参考文献
PROSIDION LIMITED
Patent: WO2005/103021 A1, 2005 ;
Location in patent: Page/Page column 16-17 ;
WO 2005/103021 A1
反应条件
N-ethyl-N,N-diisopropylamine in ethanol
8 h; Heating / reflux;
参考文献
SANOFI-AVENTIS
Patent: WO2008/58641 A1, 2008 ;
Location in patent: Page/Page column 41-42 ;
WO 2008/058641 A1
