(S)-3-氨基-1,2-丙二醇合成路线 （共 8 条）
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 59 ;
参考文献
Danklmaier, Johann; Hoenig, Helmut
Liebigs Annalen der Chemie, 1988 , p. 1149 - 1154
反应条件
ammonia in isopropyl alcohol 48 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 22 p. 3707 - 3716
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
参考文献
Synlett, , # 10 p. 1455 - 1458
反应条件
(i) NaOMe, MeOH, (ii) NH3, iPrOH; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 42, p. 1006 - 1012
参考文献
Tetrahedron Letters, , vol. 30, # 15 p. 1917 - 1920
反应条件
sodium carbonate T=20°C; 4 h;
参考文献
Ammazzalorso, Alessandra; Amoroso, Rosa; Bettoni, Giancarlo; Fantacuzzi, Marialuigia; De Filippis, Barbara; Giampietro, Letizia; Maccallini, Cristina; Paludi, Domenico; Tricca, Maria L.
Farmaco, 2004 , vol. 59, # 9 p. 685 - 690
反应条件
magnesium methanolate 1.) 110 deg C, 2 h, 2.) diethylene glycol dimethyl ether, reflux, 24 h; Yield given. Multistep reaction;
参考文献
Danielmeier, Karsten; Steckhan, Eberhard
Tetrahedron: Asymmetry, 1995 , vol. 6, # 5 p. 1181 - 1190
