(E)-3-(2-呋喃)丙烯腈合成路线 （共 27 条）
反应条件
n-ethyl morpholine; palladium diacetate in xylene
T=130°C; 6 h; Yield given. Yields of byproduct given;
参考文献
Kasahara, Akira; Izumi, Taeko; Ogihara, Takao
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 597 - 599
反应条件
n-butyllithium in tetrahydrofuran
T=-78°C; Peterson reaction; 3 h; Title compound not separated from byproducts;
参考文献
Kojima, Satoshi; Fukuzaki, Tomohide; Yamakawa, Atsushi; Murai, Yutaka
Organic Letters, 2004 , vol. 6, # 22 p. 3917 - 3920
反应条件
1: acetonitrile in tetrahydrofuran; hexane
T=-78°C; Inert atmosphere;
2: With (i-Pr2N)2BCl in tetrahydrofuran; hexanes
T=-78°C; 1 h; Inert atmosphere;
3: furfural in tetrahydrofuran; hexanes
T=-78°C; 1 h; optical yield given as percent destereoselective reaction;
参考文献
Tomioka, Takashi; Takahashi, Yusuke; Vaughan, Trey G.; Yanase, Takayoshi
Organic Letters, 2010 , vol. 12, # 10 p. 2171 - 2173
反应条件
1: aq. NaOH solution
2: aq. NaOH solution; hydroxylamine
3: water
View Scheme
参考文献
Ried; Reitz
Chemische Berichte, 1956 , vol. 89, p. 2570,2573
反应条件
silica gel; sodium carbonate
T=320°C;
参考文献
Du Pont de Nemours and Co.
Patent: US2341016 , 1941 ;
反应条件
1: diisobutylaluminium hydride / dichloromethane / -78 °C
2: Cu(ClO4)2*6H2O; trimethylsilylazide; 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,2-dichloro-ethane / 2 h / 60 °C
View Scheme
参考文献
Rokade, Balaji V.; Malekar, Sanjeev K.; Prabhu, Kandikere Ramaiah
Chemical Communications, 2012 , vol. 48, # 44 p. 5506 - 5508
反应条件
palladium diacetate in 1,4-dioxane; acetic acid
T=100°C; 8 h; other olefin with bulky substituent, use of a catalyst Pd(OAc)2/Cu(OAc)2; Product distribution;
参考文献
Fujiwara, Yuzo; Maruyama, Osamu; Yoshidomi, Michiaki; Taniguchi, Hiroshi
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 851 - 855
反应条件
tri-n-butyl-antimony
T=110°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Huang, Yao-Zeng; Shen, Yanchang; Chen, Chen
Synthetic Communications, 1989 , vol. 19, # 1, 2 p. 83 - 90
反应条件
lithium chloride in water
Wittig olefination; 0.0833333 h; Heating;
参考文献
Wu, Jinlong; Zhang, Da; Wei, Shaoyong
Synthetic Communications, 2005 , vol. 35, # 9 p. 1213 - 1222
反应条件
phosphorus pentachloride
参考文献
Gilman; Hewlett
Iowa State College Journal of Science, 1929 , vol. 4, p. 27,30
