N-苄基-6-氯-1,3-苯并噻唑-2-胺合成路线 （共 11 条）
反应条件
copper(l) chloride; sodium hydroxide in para-xylene
T=130°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Li, Feng; Shan, Haixia; Kang, Qikai; Chen, Lin
Chemical Communications, 2011 , vol. 47, # 17 p. 5058 - 5060
反应条件
iodine in dichloromethane
T=20°C; 24 h;
参考文献
Neo, Ana G.; Carrillo, Rosa M.; Marcos, Carlos F.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4850 - 4855
反应条件
1,4-diaza-bicyclo[2.2.2]octane in chloroform
参考文献
L'abbe,G. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 1159 - 1163
反应条件
1: 67 percent / CHCl3 / 1)reflux, 2)12 h room temperature
2: 71 percent / acetic acid / 0.5 h / 100 °C
3: 50 percent / H2O / 1) reflux, 2 h, 2) 12 h room temperature
4: 53 percent / tributylphosphine / toluene / 1 h / 125 - 130 °C
5: 25 percent / toluene / 3 h / Heating
View Scheme
参考文献
Finch; Ricca Jr.; Werner; Rodebaugh
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3416 - 3421
反应条件
1: 50 percent / H2O / 1) reflux, 2 h, 2) 12 h room temperature
2: 53 percent / tributylphosphine / toluene / 1 h / 125 - 130 °C
3: 25 percent / toluene / 3 h / Heating
View Scheme
参考文献
Finch; Ricca Jr.; Werner; Rodebaugh
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3416 - 3421
反应条件
1: 53 percent / tributylphosphine / toluene / 1 h / 125 - 130 °C
2: 25 percent / toluene / 3 h / Heating
View Scheme
参考文献
Finch; Ricca Jr.; Werner; Rodebaugh
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3416 - 3421
反应条件
1: 71 percent / acetic acid / 0.5 h / 100 °C
2: 50 percent / H2O / 1) reflux, 2 h, 2) 12 h room temperature
3: 53 percent / tributylphosphine / toluene / 1 h / 125 - 130 °C
4: 25 percent / toluene / 3 h / Heating
View Scheme
参考文献
Finch; Ricca Jr.; Werner; Rodebaugh
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3416 - 3421
反应条件
1: CHCl3
2: DABCO / CHCl3
View Scheme
参考文献
L'abbe,G. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 1159 - 1163
反应条件
1: water; sodium acetate / 0.5 h / 20 °C
2: iodine / dichloromethane / 24 h / 20 °C
View Scheme
参考文献
Neo, Ana G.; Carrillo, Rosa M.; Marcos, Carlos F.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4850 - 4855
反应条件
1: disulfur dichloride; acetic acid / toluene / 4.5 h / 20 - 80 °C / Cooling with ice
2: water; sodium acetate / 0.5 h / 20 °C
3: iodine / dichloromethane / 24 h / 20 °C
View Scheme
参考文献
Neo, Ana G.; Carrillo, Rosa M.; Marcos, Carlos F.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4850 - 4855
