4,4-二甲基-2,6-二氧代哌啶-3,5-二甲腈合成路线 （共 19 条）
反应条件
1: water; sulfuric acid / 12 h / |Reflux 2: acetic anhydride / 6 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 65, p. 256 - 275
反应条件
sulfuric acid; water
参考文献
Holder, Richard W.; Daub, John P.; Baker, Wesley E.; Gilbert, Raymond H; Graf, Norman A.
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1445 - 1451
参考文献
Thorpe; Wood
Journal of the Chemical Society, 1913 , vol. 103, p. 1575
Journal of the Chemical Society, 1923 , vol. 123, p. 63
反应条件
1: water; sulfuric acid / 12 h / |Reflux 2: acetic anhydride / 6 h / |Reflux 3: sodium tetrahydroborate / tetrahydrofuran / 72 h / 20 °C View Scheme
参考文献
Picha, Jan; Vanek, Vaclav; Budesinsky, Milos; Mladkova, Jana; Garrow, Timothy A.; Jiracek, Jiri
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 256 - 275
反应条件
1: 97 percent / H2SO4, H2O 2: 92 percent / H2SO4 / toluene 3: 79 percent / sodium / toluene / 28 h 4: 87 percent / 85 percent phosphoric acid / Heating View Scheme
参考文献
Holder, Richard W.; Daub, John P.; Baker, Wesley E.; Gilbert, Raymond H; Graf, Norman A.
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1445 - 1451
反应条件
1: 97 percent / H2SO4, H2O 2: 92 percent / H2SO4 / toluene View Scheme
参考文献
Handley,G.J. et al.
Australian Journal of Chemistry, 1960 , vol. 13, p. 129 - 144
反应条件
methanol; lithium nitride
T=20°C; 12 h; sealed;
参考文献
Wu, Liqiang; Yang, Chunguang; Yang, Liming; Yang, Lijuan
Heterocycles, 2009 , vol. 78, # 4 p. 977 - 982
参考文献
Thole; Thorpe
Journal of the Chemical Society, 1911 , vol. 99, p. 440
Full Text Show Details
Thorpe; Wood
Journal of the Chemical Society, 1913 , vol. 103, p. 1575
Journal of the Chemical Society, 1923 , vol. 123, p. 63
参考文献
Birch; Kon
Journal of the Chemical Society, 1923 , vol. 123, p. 2447
参考文献
Thorpe; Wood
Journal of the Chemical Society, 1913 , vol. 103, p. 1575
Journal of the Chemical Society, 1923 , vol. 123, p. 63
