pyridine; palladium diacetate; tetrabutyl-ammonium chloride in N,N-dimethyl-formamide T=100°C; P=760 Torr; 12 h;

toluene-4-sulfonic acid; hydroquinone in benzene RefluxAzeotropic water removal;

1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Wittig Olefination; 0.75 h; Inert atmosphere; 2: o-acetyl-iodobenzene With potassium tert-butylate in tetrahydrofuran; hexane T=0 - 20°C; Wittig Olefination; 4 h; Inert atmosphere;

View Scheme

in hexane; 1,2-dichloro-ethane

1.1: sulfuric acid 2.1: diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere 2.2: Cooling with ice 3.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal View Scheme

暂无反应条件数据

1: (i) Li, (ii) /BRN= 1908172/, (iii) H2O 2: (i) NaH, (ii) /BRN= 969135/ View Scheme