二氢-2H-吡喃-4(3h)-酮 肟合成路线 （共 12 条）
反应条件
hydrogenchloride in 1,4-dioxane; methanol; ethanol
参考文献
Renhowe, Paul A.; Chu, Daniel; Boyce, Rustum S.; Ni, Zhi-Jie; Duhl, David; Tozzo, Effie; Johnson, Kirk; Myles, David C.
Patent: US2002/137939 A1, 2002 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-20 - 20°C; 2 - 4 h; Heating / reflux; 2: With sodium hydroxide; water; ethyl acetate in tetrahydrofuran 3: With hydrogenchloride in diethyl ether T=0°C;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2007/36791 A1, 2007 ;
Location in patent: Page/Page column 42 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Gellibert, Francoise; De Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil; Nguyen, Van-Loc; Bertho-Ruault, Cecile; Patikis, Angela; Grygielko, Eugene T.; Laping, Nicholas J.; Huet, Stephane
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2210 - 2221
参考文献
Borsche; Thiele
Chemische Berichte, 1923 , vol. 56, p. 2012
反应条件
1-propanephosphonic acid cyclic anhydride in tetrahydrofuran; ethyl acetate T=70°C; Beckmann rearrangement; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 52, # 10 p. 1074 - 1077
反应条件
hydroxylamine hydrochloride; sodium acetate in ethanol
20 h; Heating;
参考文献
Augustine, John Kallikat; Kumar, Rajesha; Bombrun, Agnes; Mandal, Ashis Baran
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1074 - 1077
反应条件
sodium acetate in ethanol
Reflux;
参考文献
CORTEX PHARMACEUTICALS, INC.
Patent: WO2008/143963 A1, 2008 ;
Location in patent: Page/Page column 41 ;
反应条件
1: alkali dichromate; aqueous H2SO4
2: hydroxylamine
View Scheme
参考文献
Farberow et al.
Doklady Akademii Nauk SSSR, 1954 , vol. 99, p. 793,795
Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 133,135; engl. Ausg. S. 119
反应条件
1: Raney nickel; ethanol / Hydrogenation.bei Raumtemperatur unter Normaldruck
2: hydroxylamine
View Scheme
参考文献
Cornubert et al.
Bulletin de la Societe Chimique de France, 1950 , p. 40,42
