6-(氯乙酰基)-3,4-二氢喹啉-2(1H)-酮合成路线 （共 4 条）
反应条件
1: 2 h / 80 - 90 °C 2: aq. NaOH / 3 h / 60 - 70 °C View Scheme
参考文献
Tominaga; Yo; Ogawa; Yamashita; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 682 - 693
反应条件
triethylsilane; trifluoroacetic acid T=0 - 20°C;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1736474 A1, 2006 ;
Location in patent: Page/Page column 46 ;
反应条件
aluminium trichloride in carbon disulfide
3 h; Heating;
参考文献
Martinez; Walker; Hirschfeld; Bruno; Yang; Maloney
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 620 - 628
反应条件
1: 2 h / 80 - 90 °C
2: aq. NaOH / 3 h / 60 - 70 °C
3: Et3N / dimethylformamide / 1 h / Ambient temperature
4: dimethylformamide / 3 h / Ambient temperature
5: 91 percent / H2 / 10 percent Pd-C / ethanol; H2O / 45 - 50 °C
View Scheme
参考文献
Tominaga; Yo; Ogawa; Yamashita; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 682 - 693
