2-羟基-4-甲氧基-6-甲基苯甲酸乙酯合成路线 （共 18 条）
反应条件
boron tribromide in dichloromethane 0.166667 h; Ambient temperature;
参考文献
Ahad; Goto; Kiuchi; Tsuda; Kondo; Sato
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 4 p. 1043 - 1046
反应条件
potassium carbonate in acetone
3 h; Heating;
参考文献
Gramatica, Paola; Gianotti, M. Pia; Speranza, Giovanna; Manitto, Paolo
Heterocycles, 1986 , vol. 24, # 3 p. 743 - 750
反应条件
diisopropylamine in hexane; acetonitrile
T=20°C;
参考文献
EISAI CO. LTD.
Patent: WO2003/76424 A1, 2003 ;
Location in patent: Page/Page column 182 ;
反应条件
1: 88 percent / H2 / 10percent Pd/C / aq. NaOH / 15 h / 760 Torr / Ambient temperature
2: 98 percent / potassium carbonate / acetone / 3 h / Heating
View Scheme
参考文献
Gramatica, Paola; Gianotti, M. Pia; Speranza, Giovanna; Manitto, Paolo
Heterocycles, 1986 , vol. 24, # 3 p. 743 - 750
反应条件
1: 1.) n-BuLi / 1.) Et2O, 0 deg, 30 min
2: (COCl)2 / 0 - 20 °C
3: pyridine
4: BBr3 / CH2Cl2 / 0.5 h / 0 °C
View Scheme
参考文献
Broka
Tetrahedron Letters, 1991 , vol. 32, # 7 p. 859 - 862
反应条件
1: (COCl)2 / 0 - 20 °C
2: pyridine
3: BBr3 / CH2Cl2 / 0.5 h / 0 °C
View Scheme
参考文献
Broka
Tetrahedron Letters, 1991 , vol. 32, # 7 p. 859 - 862
反应条件
1: pyridine
2: BBr3 / CH2Cl2 / 0.5 h / 0 °C
View Scheme
参考文献
Broka
Tetrahedron Letters, 1991 , vol. 32, # 7 p. 859 - 862
反应条件
sodium hydroxide; nickel
参考文献
Cleaver,L. et al.
Australian Journal of Chemistry, 1976 , vol. 29, p. 1989 - 2001
参考文献
Hesse
Journal fuer Praktische Chemie (Leipzig), 1898 , vol. <2> 57, p. 306,307
Journal fuer Praktische Chemie (Leipzig), 1900 , vol. 62, p. 342
反应条件
1: 2.) D2O / 1.) -78 deg C, THF, 1 h
2: 86 percent / trityl-lithium / hexane; tetrahydrofuran / 20 h / Ambient temperature
View Scheme
参考文献
Carpenter, T. Adrian; Evans, Geoffrey E.; Leeper, Finian J.; Staunton, James; Wilkinson, Michael R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 5 p. 1043 - 1051
